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Chien Boon David Lye

rp21849

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Full Name
Chien Boon David Lye
Variants
David C. Lye
 
Main Affiliation
 
Faculty
 
Email
mdclcb@nus.edu.sg
 

Publications

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Department:  MICROBIOLOGY AND IMMUNOLOGY

Results 1-20 of 25 (Search time: 0.007 seconds).

Issue DateTitleAuthor(s)
125-May-2021A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19Yeo, Joo Guan ; Leong, Jing Yao ; Tay, Shi Huan; Nadua, Karen Donceras ; Anderson, Danielle E. ; Lim, Amanda Jin Mei; Ng, Xiang Wen; Poh, Su Li; Guo, Dianyan; Yaung, Katherine Nay; Kumar, Pavanish; Wasser, Martin ; Hazirah, Sharifah Nur; Sutamam, Nursyuhadah; Chua, Camillus Jian Hui; Qui, Martin; Foo, Randy ; Gamage, Akshamal Mihiranga ; Yeo, Kee Thai ; Ramakrishna, Lakshmi; Arkachaisri, Thaschawee ; Young, Barnaby E.; Lye, David Chien ; Wang, Lin-Fa ; Chong, Chia Yin ; Tan, Natalie Woon Hui ; Li, Jiahui ; Kam, Kai-Qian ; Ginhoux, Florent ; Thoon, Koh Cheng ; Chan, Jerry Kok Yen ; Yung, Chee Fu ; Albani, Salvatore 
231-Aug-2023Acquisition of regulator on virulence plasmid of hypervirulent Klebsiella allows bacterial lifestyle switch in response to ironChu, Wilson HW ; Tan, Yi Han ; Tan, Si Yin ; Chen, Yahua ; Yong, Melvin ; Lye, David C ; Kalimuddin, Shirin ; Archuleta, Sophia ; Gan, Yunn-Hwen 
31-Apr-2021Association of SARS-CoV-2 clades with clinical, inflammatory and virologic outcomes: An observational studyYoung, Barnaby E; Wei, Wycliffe E; Fong, Siew-Wai; Mak, Tze-Minn; Anderson, Danielle E ; Chan, Yi-Hao; Pung, Rachael; Heng, Cheryl SY; Ang, Li Wei; Zheng, Adrian Kang Eng; Lee, Bernett; Kalimuddin, Shirin ; Pada, Surinder ; Tambyah, Paul A ; Parthasarathy, Purnima; Tan, Seow Yen; Sun, Louisa; Smith, Gavin JD; Lin, Raymond Tzer Pin; Leo, Yee-Sin ; Renia, Laurent ; Wang, Lin-Fa; Ng, Lisa FP; Maurer-Stroh, Sebastian; Lye, David Chien ; Lee, Vernon J 
421-Jun-2021Author Correction: Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity (Scientific Reports, (2017), 7, 1, (46191), 10.1038/srep46191)Tang, Tommy Hing-Cheung; Alonso, Sylvie ; Ng, Lisa Fong-Poh ; Thein, Tun-Linn; Pang, Junxiong ; Leo, Yee-Sin ; Lye, David Chien-Boon ; Yeo, Tsin-Wen
515-Feb-2021Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activationChioh, Florence WJ; Fong, Siew-Wai ; Young, Barnaby E; Wu, Kan-Xing; Siau, Anthony; Krishnan, Shuba; Chan, Yi-Hao; Carissimo, Guillaume; Teo, Louis LY; Gao, Fei ; Tan, Ru San ; Zhong, Liang ; Koh, Angela S; Tan, Seow-Yen; Tambyah, Paul A ; Renia, Laurent ; Ng, Lisa FP; Lye, David C ; Cheung, Christine 
616-Jun-2023Cost-minimization analysis of oral versus intravenous antibiotic treatment for <i>Klebsiella pneumoniae</i> liver abscessYoong, Joanne ; Yuen, Kah Hung ; Molton, James S ; Ding, Ying ; Cher, Boon Piang ; Chan, Monica; Kalimuddin, Shirin ; Oon, Jolene ; Young, Barnaby; Low, Jenny ; Salada, Brenda MA; Lee, Tau Hong; Wijaya, Li Min; Fisher, Dale ; Izharuddin, Ezlyn; Wei, Yuan ; Phillips, Rachel ; Moorakonda, Rajesh ; Lye, David C ; Archuleta, Sophia 
721-Jan-2022Decreased memory B cell frequencies in COVID-19 delta variant vaccine breakthrough infectionTay, Matthew Zirui; Rouers, Angeline; Fong, Siew-Wai ; Goh, Yun Shan; Chan, Yi-Hao; Chang, Zi Wei; Xu, Weili; Tan, Chee Wah ; Chia, Wan Ni ; Torres-Ruesta, Anthony; Amrun, Siti Naqiah; Huang, Yuling; Hor, Pei Xiang; Loh, Chiew Yee ; Yeo, Nicholas Kim-Wah; Wang, Bei ; Ngoh, Eve Zi Xian; Salleh, Siti Nazihah Mohd; Chavatte, Jean-Marc; Lim, Alicia Jieling; Maurer-Stroh, Sebastian ; Wang, Lin-Fa ; Lin, Raymond Valentine Tzer Pin ; Wang, Cheng-I; Tan, Seow-Yen; Young, Barnaby Edward; Leo, Yee-Sin ; Lye, David C ; Renia, Laurent ; Ng, Lisa FP
81-Jun-2021Dynamics of SARS-CoV-2 neutralising antibody responses and duration of immunity: a longitudinal study.Wan Ni Chia ; Feng Zhu ; Sean Wei Xiang Ong; Barnaby Edward Young; Siew Wai Fong; Nina Le Bert ; Chee Wah Tan ; Charles Tiu; Jinyan Zhang ; Seow Yen Tan; Surinder Pada ; Yi Hao Chan; Christine Y.L. Tham; Kamini Kunasegaran ; Mark I.C. Chen ; Jenny G.H. Low ; Yee Sin Leo ; Laurent Renia ; Antonio Bertoletti ; Lisa F.P. Ng; David Chien Lye ; Lin Fa Wan
91-Feb-2021Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patientsTan, Anthony T. ; Linster, Martin ; Tan, Chee Wah ; Le Bert, Nina ; Chia, Wan Ni ; Kunasegaran, Kamini ; Zhuang, Yan ; Tham, Christine Y. L.; Chia, Adeline; Smith, Gavin J. D. ; Young, Barnaby; Kalimuddin, Shirin ; Low, Jenny G. H. ; Lye, David ; Wang, Lin-Fa ; Bertoletti, Antonio 
1019-Jul-2022Early oral stepdown antibiotic therapy versus continuing intravenous therapy for uncomplicated Gram-negative bacteraemia (the INVEST trial): study protocol for a multicentre, randomised controlled, open-label, phase III, non-inferiority trialLee, I Russel ; Tong, Steven YC; Davis, Joshua S; Paterson, David L; Syed-Omar, Sharifah F; Peck, Kwong Ran; Chung, Doo Ryeon; Cooke, Graham S; Libau, Eshele Anak ; Rahman, Siti-Nabilah BA ; Gandhi, Mihir P ; Shi, Luming ; Zheng, Shuwei ; Chaung, Jenna; Tan, Seow Yen; Kalimuddin, Shirin ; Archuleta, Sophia ; Lye, David C 
1127-Oct-2022Early pathogenesis profiles across SARS-CoV-2 variants in K18-hACE2 mice revealed differential triggers of lung damagesAw, Zhen Qin ; Mok, Chee Keng ; Wong, Yi Hao ; Chen, Huixin ; Mak, Tze Minn; Lin, Raymond TP ; Lye, David Chien ; Tan, Kai Sen ; Chu, Justin Jang Hann 
1229-Aug-2020Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort studyYoung, Barnaby E; Fong, Siew-Wai; Chan, Yi-Hao; Mak, Tze-Minn; Ang, Li Wei; Anderson, Danielle E ; Lee, Cheryl Yi-Pin; Amrun, Siti Naqiah ; Lee, Bernett; Goh, Yun Shan; Su, Yvonne CF; Wei, Wycliffe E; Kalimuddin, Shirin ; Chai, Louis Yi Ann ; Pada, Surinder ; Tan, Seow Yen; Sun, Louisa; Parthasarathy, Purnima; Chen, Yuan Yi Constance; Barkham, Timothy; Lin, Raymond Tzer Pin ; Maurer-Stroh, Sebastian; Leo, Yee-Sin ; Wang, Lin-Fa; Renia, Laurent ; Lee, Vernon J ; Smith, Gavin JD ; Lye, David Chien ; Ng, Lisa FP
1316-Nov-2022Efficient recall of SARS-CoV-2 variant-reactive B cells and T responses in the elderly upon heterologous mRNA vaccines as boostersRouers, Angeline; Wong, Nathan; Goh, Yun Shan; Torres-Ruesta, Anthony; Tay, Matthew Zirui; Chang, Zi Wei; Fong, Siew-Wai ; Neo, Vanessa; Kam, Isaac Kai Jie; Yeo, Nicholas Kim-Wah; Huang, Yuling; Loh, Chiew Yee; Hor, Pei Xiang; Wong, Joel Xu En; Tan, Yong Jie; Macary, Paul A ; Qian, Xinlei; Wang Bei ; Ngoh, Eve Zi Xian; Salleh, Siti Nazihah Mohd; Wang, Cheng-; Poh, Xuan Ying; Rao, Suma; Chia, Po Ying; Ong, Sean WX; Lee, Tau Hong; Lin, Ray JH; Lim, Clarissa ; Teo, Jefanie; Ren, Ee Chee ; Lye, David Chien ; Young, Barnaby E; Ng, Lisa FP ; Renia, Laurent 
143-May-2021Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infectionLe Bert, Nina ; Clapham, Hannah E ; Tan, Anthony T ; Chia, Wan Ni ; Tham, Christine YL; Lim, Jane M; Kunasegaran, Kamini; Tan, Linda Wei Lin; Dutertre, Charles-Antoine; Shankar, Nivedita; Lim, Joey ME; Sun, Louisa Jin; Zahari, Marina; Tun, Zaw Myo; Kumar, Vishakha; Lim, Beng Lee ; Lim, Siew Hoon; Chia, Adeline; Tan, Yee-Joo ; Tambyah, Paul Anantharajah ; Kalimuddin, Shirin ; Lye, David ; Low, Jenny GH ; Wang, Lin-Fa ; Wan, Wei Yee ; Hsu, Li Yang ; Bertoletti, Antonio ; Tam, Clarence C 
1517-Dec-2019Large-Scale HLA Tetramer Tracking of T Cells during Dengue Infection Reveals Broad Acute Activation and Differentiation into Two Memory Cell FatesChng, Melissa Hui Yen ; Lim, Mei Qiu ; Rouers, Angeline; Becht, Etienne; Lee, Bernett; MacAry, Paul A ; Lye, David Chien ; Leo, Yee Sin ; Chen, Jinmiao ; Fink, Katja; Rivino, Laura ; Newell, Evan W 
161-Sep-2020Metagenome-wide association analysis identifies microbial determinants of post-antibiotic ecological recovery in the gutChng, KR; Ghosh, TS; Tan, YH ; Nandi, T; Lee, IR ; Ng, AHQ; Li, C; Ravikrishnan, A; Lim, KM; Lye, D ; Barkham, T ; Raman, K; Chen, SL ; Chai, L ; Young, B; Gan, YH ; Nagarajan, N 
172019NK cells are activated and primed for skin-homing during acute dengue virus infection in humansZimmer, C.L.; Cornillet, M.; Solà-Riera, C.; Cheung, K.-W.; Ivarsson, M.A.; Lim, M.Q.; Marquardt, N.; Leo, Y.-S. ; Lye, D.C. ; Klingström, J.; MacAry, P.A. ; Ljunggren, H.-G.; Rivino, L.; Björkström, N.K.
18Jun-2021Persistent Symptoms and Association With Inflammatory Cytokine Signatures in Recovered Coronavirus Disease 2019 Patients.Ong, Sean Wei Xiang; Fong, Siew-Wai; Young, Barnaby Edward; Chan, Yi-Hao; Lee, Bernett; Amrun, Siti Naqiah ; Chee, Rhonda Sin-Ling; Yeo, Nicholas Kim-Wah; Tambyah, Paul ; Pada, Surinder ; Tan, Seow Yen; Ding, Ying; Renia, Laurent ; Leo, Yee-Sin ; Ng, Lisa FP; Lye, David Chien 
1922-Apr-2017Prophylactic platelet transfusion plus supportive care versus supportive care alone in adults with dengue and thrombocytopenia: a multicentre, open-label, randomised, superiority trialLye, David C ; Archuleta, Sophia ; Syed-Omar, Sharifah F; Low, Jenny G ; Oh, Helen M; Wei, Yuan; Fisher, Dale ; Ponnampalavanar, Sasheela SL; Wijaya, Limin ; Lee, Linda K; Ooi, Eng-Eong ; Kamarulzaman, Adeeba; Lum, Lucy C; Tambyah, Paul A ; Leo, Yee-Sin 
2016-Feb-2021Sensitive detection of total anti-Spike antibodies and isotype switching in asymptomatic and symptomatic individuals with COVID-19Goh, YS; Chavatte, JM; Lim Jieling, A ; Lee, B; Hor, PX; Amrun, SN ; Lee, CYP; Chee, RSL; Wang, B ; Lee, CY; Ngoh, EZX; Wang, CI; Young, BE; Tambyah, PA ; Kalimuddin, S ; Pada, S ; Tan, SY; Sun, LJ; Chen, MIC ; Leo, YS ; Lye, DC ; Ng, LFP; Lin, RTP ; Renia, L