Please use this identifier to cite or link to this item: https://doi.org/10.7554/eLife.64909
Title: Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation
Authors: Chioh, Florence WJ
Fong, Siew-Wai 
Young, Barnaby E
Wu, Kan-Xing
Siau, Anthony
Krishnan, Shuba
Chan, Yi-Hao
Carissimo, Guillaume
Teo, Louis LY
Gao, Fei 
Tan, Ru San 
Zhong, Liang 
Koh, Angela S
Tan, Seow-Yen
Tambyah, Paul A 
Renia, Laurent 
Ng, Lisa FP
Lye, David C 
Cheung, Christine 
Keywords: Science & Technology
Life Sciences & Biomedicine
Biology
Life Sciences & Biomedicine - Other Topics
ACUTE RESPIRATORY SYNDROME
PROGENITOR CELLS
GROWTH-FACTOR
VASCULAR FUNCTION
IDENTIFICATION
TRAFFICKING
CYTOKINES
BIOMARKER
CAPACITY
DISEASE
Issue Date: 15-Feb-2021
Publisher: eLIFE SCIENCES PUBL LTD
Citation: Chioh, Florence WJ, Fong, Siew-Wai, Young, Barnaby E, Wu, Kan-Xing, Siau, Anthony, Krishnan, Shuba, Chan, Yi-Hao, Carissimo, Guillaume, Teo, Louis LY, Gao, Fei, Tan, Ru San, Zhong, Liang, Koh, Angela S, Tan, Seow-Yen, Tambyah, Paul A, Renia, Laurent, Ng, Lisa FP, Lye, David C, Cheung, Christine (2021-02-15). Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation. ELIFE 10. ScholarBank@NUS Repository. https://doi.org/10.7554/eLife.64909
Abstract: Numerous reports of vascular events after an initial recovery from COVID-19 form our impetus to investigate the impact of COVID-19 on vascular health of recovered patients. We found elevated levels of circulating endothelial cells (CECs), a biomarker of vascular injury, in COVID-19 convalescents compared to healthy controls. In particular, those with pre-existing conditions (e.g., hypertension, diabetes) had more pronounced endothelial activation hallmarks than non-COVID-19 patients with matched cardiovascular risk. Several proinflammatory and activated T lymphocyte-associated cytokines sustained from acute infection to recovery phase, which correlated positively with CEC measures, implicating cytokine-driven endothelial dysfunction. Notably, we found higher frequency of effector T cells in our COVID-19 convalescents compared to healthy controls. The activation markers detected on CECs mapped to counter receptors found primarily on cytotoxic CD8+ T cells, raising the possibility of cytotoxic effector cells targeting activated endothelial cells. Clinical trials in preventive therapy for post-COVID-19 vascular complications may be needed.
Source Title: ELIFE
URI: https://scholarbank.nus.edu.sg/handle/10635/226647
ISSN: 2050084X
DOI: 10.7554/eLife.64909
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