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Title: Decreased memory B cell frequencies in COVID-19 delta variant vaccine breakthrough infection
Authors: Tay, Matthew Zirui
Rouers, Angeline
Fong, Siew-Wai 
Goh, Yun Shan
Chan, Yi-Hao
Chang, Zi Wei
Xu, Weili
Tan, Chee Wah 
Chia, Wan Ni 
Torres-Ruesta, Anthony
Amrun, Siti Naqiah
Huang, Yuling
Hor, Pei Xiang
Loh, Chiew Yee 
Yeo, Nicholas Kim-Wah
Wang, Bei 
Ngoh, Eve Zi Xian
Salleh, Siti Nazihah Mohd
Chavatte, Jean-Marc
Lim, Alicia Jieling
Maurer-Stroh, Sebastian 
Wang, Lin-Fa 
Lin, Raymond Valentine Tzer Pin 
Wang, Cheng-I
Tan, Seow-Yen
Young, Barnaby Edward
Leo, Yee-Sin 
Lye, David C 
Renia, Laurent 
Ng, Lisa FP
Keywords: Science & Technology
Life Sciences & Biomedicine
Medicine, Research & Experimental
Research & Experimental Medicine
correlate of risk
memory B cells
vaccine breakthrough
Issue Date: 21-Jan-2022
Publisher: WILEY
Citation: Tay, Matthew Zirui, Rouers, Angeline, Fong, Siew-Wai, Goh, Yun Shan, Chan, Yi-Hao, Chang, Zi Wei, Xu, Weili, Tan, Chee Wah, Chia, Wan Ni, Torres-Ruesta, Anthony, Amrun, Siti Naqiah, Huang, Yuling, Hor, Pei Xiang, Loh, Chiew Yee, Yeo, Nicholas Kim-Wah, Wang, Bei, Ngoh, Eve Zi Xian, Salleh, Siti Nazihah Mohd, Chavatte, Jean-Marc, Lim, Alicia Jieling, Maurer-Stroh, Sebastian, Wang, Lin-Fa, Lin, Raymond Valentine Tzer Pin, Wang, Cheng-I, Tan, Seow-Yen, Young, Barnaby Edward, Leo, Yee-Sin, Lye, David C, Renia, Laurent, Ng, Lisa FP (2022-01-21). Decreased memory B cell frequencies in COVID-19 delta variant vaccine breakthrough infection. EMBO MOLECULAR MEDICINE 14 (3). ScholarBank@NUS Repository.
Abstract: The SARS-CoV-2 Delta (B.1.617.2) variant is capable of infecting vaccinated persons. An open question remains as to whether deficiencies in specific vaccine-elicited immune responses result in susceptibility to vaccine breakthrough infection. We investigated 55 vaccine breakthrough infection cases (mostly Delta) in Singapore, comparing them against 86 vaccinated close contacts who did not contract infection. Vaccine breakthrough cases showed lower memory B cell frequencies against SARS-CoV-2 receptor-binding domain (RBD). Compared to plasma antibodies, antibodies secreted by memory B cells retained a higher fraction of neutralizing properties against the Delta variant. Inflammatory cytokines including IL-1β and TNF were lower in vaccine breakthrough infections than primary infection of similar disease severity, underscoring the usefulness of vaccination in preventing inflammation. This report highlights the importance of memory B cells against vaccine breakthrough and suggests that lower memory B cell levels may be a correlate of risk for Delta vaccine breakthrough infection.
ISSN: 17574676
DOI: 10.15252/emmm.202115227
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