Please use this identifier to cite or link to this item: https://doi.org/10.1126/science.aau0964
Title: Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches
Authors: Chakarov, Svetoslav
Lim, Hwee Ying 
Tan, Leonard
Lim, Sheau Yng 
See, Peter
Lum, Josephine
Zhang, Xiao-Meng
Foo, Shihui
Nakamizo, Satoshi
Duan, Kaibo
Kong, Wan Ting 
Gentek, Rebecca
Balachander, Akhila
Carbajo, Daniel
Bleriot, Camille
Malleret, Benoit 
Tam, John Kit Chung 
Baig, Sonia 
Shabeer, Muhammad
Toh, Sue-Anne Ee Shiow 
Schlitzer, Andreas
Larbi, Anis 
Marichal, Thomas
Malissen, Bernard
Chen, Jinmiao 
Poidinger, Michael
Kabashima, Kenji
Bajenoff, Marc
Ng, Lai Guan 
Angeli, Veronique 
Ginhoux, Florent 
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
RESIDENT CARDIAC MACROPHAGES
INDUCED PULMONARY-FIBROSIS
DENDRITIC CELLS
FETAL MONOCYTES
LYVE-1-POSITIVE MACROPHAGES
EXPRESSION
IDENTIFICATION
RECEPTOR
REVEALS
FATE
Issue Date: 15-Mar-2019
Publisher: AMER ASSOC ADVANCEMENT SCIENCE
Citation: Chakarov, Svetoslav, Lim, Hwee Ying, Tan, Leonard, Lim, Sheau Yng, See, Peter, Lum, Josephine, Zhang, Xiao-Meng, Foo, Shihui, Nakamizo, Satoshi, Duan, Kaibo, Kong, Wan Ting, Gentek, Rebecca, Balachander, Akhila, Carbajo, Daniel, Bleriot, Camille, Malleret, Benoit, Tam, John Kit Chung, Baig, Sonia, Shabeer, Muhammad, Toh, Sue-Anne Ee Shiow, Schlitzer, Andreas, Larbi, Anis, Marichal, Thomas, Malissen, Bernard, Chen, Jinmiao, Poidinger, Michael, Kabashima, Kenji, Bajenoff, Marc, Ng, Lai Guan, Angeli, Veronique, Ginhoux, Florent (2019-03-15). Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches. SCIENCE 363 (6432) : 1190-+. ScholarBank@NUS Repository. https://doi.org/10.1126/science.aau0964
Abstract: 2017 © The Authors. Macrophages are a heterogeneous cell population involved in tissue homeostasis, inflammation, and various pathologies. Although the major tissue-resident macrophage populations have been extensively studied, interstitial macrophages (IMs) residing within the tissue parenchyma remain poorly defined. Here we studied IMs from murine lung, fat, heart, and dermis. We identified two independent IM subpopulations that are conserved across tissues: Lyve1 lo MHCII hi CX3CR1 hi (Lyve1 lo MHCII hi ) and Lyve1 hi MHCII lo CX3CR1 lo (Lyve1 hi MHCII lo ) monocyte-derived IMs, with distinct gene expression profiles, phenotypes, functions, and localizations. Using a new mouse model of inducible macrophage depletion (Slco2b1 flox/DTR ), we found that the absence of Lyve1 hi MHCII lo IMs exacerbated experimental lung fibrosis. Thus, we demonstrate that two independent populations of IMs coexist across tissues and exhibit conserved niche-dependent functional programming.
Source Title: SCIENCE
URI: https://scholarbank.nus.edu.sg/handle/10635/155393
ISSN: 0036-8075
1095-9203
DOI: 10.1126/science.aau0964
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