Please use this identifier to cite or link to this item: https://doi.org/10.1126/science.aau0964
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dc.titleTwo distinct interstitial macrophage populations coexist across tissues in specific subtissular niches
dc.contributor.authorChakarov, Svetoslav
dc.contributor.authorLim, Hwee Ying
dc.contributor.authorTan, Leonard
dc.contributor.authorLim, Sheau Yng
dc.contributor.authorSee, Peter
dc.contributor.authorLum, Josephine
dc.contributor.authorZhang, Xiao-Meng
dc.contributor.authorFoo, Shihui
dc.contributor.authorNakamizo, Satoshi
dc.contributor.authorDuan, Kaibo
dc.contributor.authorKong, Wan Ting
dc.contributor.authorGentek, Rebecca
dc.contributor.authorBalachander, Akhila
dc.contributor.authorCarbajo, Daniel
dc.contributor.authorBleriot, Camille
dc.contributor.authorMalleret, Benoit
dc.contributor.authorTam, John Kit Chung
dc.contributor.authorBaig, Sonia
dc.contributor.authorShabeer, Muhammad
dc.contributor.authorToh, Sue-Anne Ee Shiow
dc.contributor.authorSchlitzer, Andreas
dc.contributor.authorLarbi, Anis
dc.contributor.authorMarichal, Thomas
dc.contributor.authorMalissen, Bernard
dc.contributor.authorChen, Jinmiao
dc.contributor.authorPoidinger, Michael
dc.contributor.authorKabashima, Kenji
dc.contributor.authorBajenoff, Marc
dc.contributor.authorNg, Lai Guan
dc.contributor.authorAngeli, Veronique
dc.contributor.authorGinhoux, Florent
dc.date.accessioned2019-06-07T02:07:59Z
dc.date.available2019-06-07T02:07:59Z
dc.date.issued2019-03-15
dc.identifier.citationChakarov, Svetoslav, Lim, Hwee Ying, Tan, Leonard, Lim, Sheau Yng, See, Peter, Lum, Josephine, Zhang, Xiao-Meng, Foo, Shihui, Nakamizo, Satoshi, Duan, Kaibo, Kong, Wan Ting, Gentek, Rebecca, Balachander, Akhila, Carbajo, Daniel, Bleriot, Camille, Malleret, Benoit, Tam, John Kit Chung, Baig, Sonia, Shabeer, Muhammad, Toh, Sue-Anne Ee Shiow, Schlitzer, Andreas, Larbi, Anis, Marichal, Thomas, Malissen, Bernard, Chen, Jinmiao, Poidinger, Michael, Kabashima, Kenji, Bajenoff, Marc, Ng, Lai Guan, Angeli, Veronique, Ginhoux, Florent (2019-03-15). Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches. SCIENCE 363 (6432) : 1190-+. ScholarBank@NUS Repository. https://doi.org/10.1126/science.aau0964
dc.identifier.issn0036-8075
dc.identifier.issn1095-9203
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/155393
dc.description.abstract2017 © The Authors. Macrophages are a heterogeneous cell population involved in tissue homeostasis, inflammation, and various pathologies. Although the major tissue-resident macrophage populations have been extensively studied, interstitial macrophages (IMs) residing within the tissue parenchyma remain poorly defined. Here we studied IMs from murine lung, fat, heart, and dermis. We identified two independent IM subpopulations that are conserved across tissues: Lyve1 lo MHCII hi CX3CR1 hi (Lyve1 lo MHCII hi ) and Lyve1 hi MHCII lo CX3CR1 lo (Lyve1 hi MHCII lo ) monocyte-derived IMs, with distinct gene expression profiles, phenotypes, functions, and localizations. Using a new mouse model of inducible macrophage depletion (Slco2b1 flox/DTR ), we found that the absence of Lyve1 hi MHCII lo IMs exacerbated experimental lung fibrosis. Thus, we demonstrate that two independent populations of IMs coexist across tissues and exhibit conserved niche-dependent functional programming.
dc.language.isoen
dc.publisherAMER ASSOC ADVANCEMENT SCIENCE
dc.sourceElements
dc.subjectScience & Technology
dc.subjectMultidisciplinary Sciences
dc.subjectScience & Technology - Other Topics
dc.subjectRESIDENT CARDIAC MACROPHAGES
dc.subjectINDUCED PULMONARY-FIBROSIS
dc.subjectDENDRITIC CELLS
dc.subjectFETAL MONOCYTES
dc.subjectLYVE-1-POSITIVE MACROPHAGES
dc.subjectEXPRESSION
dc.subjectIDENTIFICATION
dc.subjectRECEPTOR
dc.subjectREVEALS
dc.subjectFATE
dc.typeArticle
dc.date.updated2019-06-04T03:24:43Z
dc.contributor.departmentDEPT OF MEDICINE
dc.contributor.departmentDEPT OF PHYSIOLOGY
dc.description.doi10.1126/science.aau0964
dc.description.sourcetitleSCIENCE
dc.description.volume363
dc.description.issue6432
dc.description.page1190-+
dc.published.statePublished
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