Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.immuni.2021.07.007
Title: Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease
Authors: Mulder, Kevin
Patel, Amit Ashok
Kong, Wan Ting 
Piot, Cecile
Halitzki, Evelyn
Dunsmore, Garett
Khalilnezhad, Shabnam
Irac, Sergio Erdal
Dubuisson, Agathe
Chevrier, Marion
Zhang, Xiao Meng
Tam, John Kit Chung 
Lim, Tony Kiat Hon
Wong, Regina Men Men
Pai, Rhea
Khalil, Ahmed Ibrahim Samir
Chow, Pierce Kah Hoe 
Wu, Suny Z
Al-Eryani, Ghamdan
Roden, Daniel
Swarbrick, Alexander
Chan, Jerry Kok Yen 
Albani, Salvatore 
Derosa, Lisa
Zitvogel, Laurence
Sharma, Ankur
Chen, Jinmiao 
Silvin, Aymeric
Bertoletti, Antonio 
Bleriot, Camille
Dutertre, Charles-Antoine 
Ginhoux, Florent 
Keywords: Science & Technology
Life Sciences & Biomedicine
Immunology
DENDRITIC CELLS
T-CELLS
DISTINCT
EXPRESSION
SUBSETS
REVEALS
DRIVES
TRANSCRIPTOMICS
IDENTIFICATION
NOMENCLATURE
Issue Date: 10-Aug-2021
Publisher: CELL PRESS
Citation: Mulder, Kevin, Patel, Amit Ashok, Kong, Wan Ting, Piot, Cecile, Halitzki, Evelyn, Dunsmore, Garett, Khalilnezhad, Shabnam, Irac, Sergio Erdal, Dubuisson, Agathe, Chevrier, Marion, Zhang, Xiao Meng, Tam, John Kit Chung, Lim, Tony Kiat Hon, Wong, Regina Men Men, Pai, Rhea, Khalil, Ahmed Ibrahim Samir, Chow, Pierce Kah Hoe, Wu, Suny Z, Al-Eryani, Ghamdan, Roden, Daniel, Swarbrick, Alexander, Chan, Jerry Kok Yen, Albani, Salvatore, Derosa, Lisa, Zitvogel, Laurence, Sharma, Ankur, Chen, Jinmiao, Silvin, Aymeric, Bertoletti, Antonio, Bleriot, Camille, Dutertre, Charles-Antoine, Ginhoux, Florent (2021-08-10). Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease. IMMUNITY 54 (8) : 1883-+. ScholarBank@NUS Repository. https://doi.org/10.1016/j.immuni.2021.07.007
Abstract: Mononuclear phagocytes (MNPs) encompass dendritic cells, monocytes, and macrophages (MoMac), which exhibit antimicrobial, homeostatic, and immunoregulatory functions. We integrated 178,651 MNPs from 13 tissues across 41 datasets to generate a MNP single-cell RNA compendium (MNP-VERSE), a publicly available tool to map MNPs and define conserved gene signatures of MNP populations. Next, we generated a MoMac-focused compendium that revealed an array of specialized cell subsets widely distributed across multiple tissues. Specific pathological forms were expanded in cancer and inflammation. All neoplastic tissues contained conserved tumor-associated macrophage populations. In particular, we focused on IL4I1+CD274(PD-L1)+IDO1+ macrophages, which accumulated in the tumor periphery in a T cell-dependent manner via interferon-γ (IFN-γ) and CD40/CD40L-induced maturation from IFN-primed monocytes. IL4I1_Macs exhibited immunosuppressive characteristics through tryptophan degradation and promoted the entry of regulatory T cell into tumors. This integrated analysis provides a robust online-available platform for uniform annotation and dissection of specific macrophage functions in healthy and pathological states.
Source Title: IMMUNITY
URI: https://scholarbank.nus.edu.sg/handle/10635/234726
ISSN: 1074-7613
1097-4180
DOI: 10.1016/j.immuni.2021.07.007
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