Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41467-022-32312-1
Title: Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine dose
Authors: Renia, Laurent 
Goh, Yun Shan
Rouers, Angeline
Le Bert, Nina 
Chia, Wan Ni 
Chavatte, Jean-Marc
Fong, Siew-Wai 
Chang, Zi Wei
Zhuo, Nicole Ziyi
Tay, Matthew Zirui
Chan, Yi-Hao
Tan, Chee Wah 
Yeo, Nicholas Kim-Wah
Amrun, Siti Naqiah 
Huang, Yuling
Wong, Joel Xu En
Hor, Pei Xiang
Loh, Chiew Yee 
Wang, Bei 
Ngoh, Eve Zi Xian
Salleh, Siti Nazihah Mohd
Carissimo, Guillaume 
Dowla, Samanzer
Lim, Alicia Jieling
Zhang, Jinyan 
Lim, Joey Ming Er
Wang, Cheng-I
Ding, Ying 
Pada, Surinder 
Sun, Louisa Jin
Somani, Jyoti 
Lee, Eng Sing
Ong, Desmond Luan Seng 
Leo, Yee-Sin 
MacAry, Paul A 
Lin, Raymond Tzer Pin 
Wang, Lin-Fa 
Ren, Ee Chee 
Lye, David C
Bertoletti, Antonio 
Young, Barnaby Edward
Ng, Lisa FP
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
AGED GREATER-THAN-OR-EQUAL-TO-65 YEARS
MESSENGER-RNA VACCINE
COVID-19 VACCINES
NEUTRALIZING ANTIBODIES
SARS-COV-2 INFECTION
T-CELL
IMMUNOGENICITY
MULTICENTER
RESPONSES
OMICRON
Issue Date: 8-Aug-2022
Publisher: NATURE PORTFOLIO
Citation: Renia, Laurent, Goh, Yun Shan, Rouers, Angeline, Le Bert, Nina, Chia, Wan Ni, Chavatte, Jean-Marc, Fong, Siew-Wai, Chang, Zi Wei, Zhuo, Nicole Ziyi, Tay, Matthew Zirui, Chan, Yi-Hao, Tan, Chee Wah, Yeo, Nicholas Kim-Wah, Amrun, Siti Naqiah, Huang, Yuling, Wong, Joel Xu En, Hor, Pei Xiang, Loh, Chiew Yee, Wang, Bei, Ngoh, Eve Zi Xian, Salleh, Siti Nazihah Mohd, Carissimo, Guillaume, Dowla, Samanzer, Lim, Alicia Jieling, Zhang, Jinyan, Lim, Joey Ming Er, Wang, Cheng-I, Ding, Ying, Pada, Surinder, Sun, Louisa Jin, Somani, Jyoti, Lee, Eng Sing, Ong, Desmond Luan Seng, Leo, Yee-Sin, MacAry, Paul A, Lin, Raymond Tzer Pin, Wang, Lin-Fa, Ren, Ee Chee, Lye, David C, Bertoletti, Antonio, Young, Barnaby Edward, Ng, Lisa FP (2022-08-08). Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine dose. NATURE COMMUNICATIONS 13 (1). ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-022-32312-1
Abstract: Understanding the impact of age on vaccinations is essential for the design and delivery of vaccines against SARS-CoV-2. Here, we present findings from a comprehensive analysis of multiple compartments of the memory immune response in 312 individuals vaccinated with the BNT162b2 SARS-CoV-2 mRNA vaccine. Two vaccine doses induce high antibody and T cell responses in most individuals. However, antibody recognition of the Spike protein of the Delta and Omicron variants is less efficient than that of the ancestral Wuhan strain. Age-stratified analyses identify a group of low antibody responders where individuals ≥60 years are overrepresented. Waning of the antibody and cellular responses is observed in 30% of the vaccinees after 6 months. However, age does not influence the waning of these responses. Taken together, while individuals ≥60 years old take longer to acquire vaccine-induced immunity, they develop more sustained acquired immunity at 6 months post-vaccination. A third dose strongly boosts the low antibody responses in the older individuals against the ancestral Wuhan strain, Delta and Omicron variants.
Source Title: NATURE COMMUNICATIONS
URI: https://scholarbank.nus.edu.sg/handle/10635/234731
ISSN: 2041-1723
DOI: 10.1038/s41467-022-32312-1
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third v.pdf3.1 MBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

1
checked on Nov 21, 2022

Page view(s)

9
checked on Nov 24, 2022

Download(s)

1
checked on Nov 24, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.