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https://doi.org/10.1016/j.vaccine.2020.06.007
Title: | COVID-19 vaccine development: Time to consider SARS-CoV-2 challenge studies? Comment | Authors: | Schaefer, G Owen Tam, Clarence C Savulescu, Julian Voo, Teck Chuan |
Keywords: | Science & Technology Life Sciences & Biomedicine Immunology Medicine, Research & Experimental Research & Experimental Medicine Covid-19 Coronavirus Pandemic Human challenge study Ethics Vaccine |
Issue Date: | 14-Jul-2020 | Publisher: | ELSEVIER SCI LTD | Citation: | Schaefer, G Owen, Tam, Clarence C, Savulescu, Julian, Voo, Teck Chuan (2020-07-14). COVID-19 vaccine development: Time to consider SARS-CoV-2 challenge studies? Comment. VACCINE 38 (33) : 5085-5088. ScholarBank@NUS Repository. https://doi.org/10.1016/j.vaccine.2020.06.007 | Abstract: | While a human challenge study holds the prospect of accelerating the development of a vaccine for the coronavirus SARS-CoV-2, it may be opposed due to risks of harm to participants and researchers. Given the increasing number of human deaths and severe disruption to lives worldwide, we argue that a SARS-CoV-2 challenge study is ethically justifiable as its social value substantially outweighs the risks. Such a study should therefore be seriously considered as part of the global research response towards the COVID-19 pandemic. In this paper, we contribute to the debate by addressing the misperception that a challenge study for the coronavirus would lower scientific and ethical standards for vaccine research and development, and examine how it could be ethically conducted. We also set out information that needs to be disclosed to prospective participants to obtain their consent. | Source Title: | VACCINE | URI: | https://scholarbank.nus.edu.sg/handle/10635/228280 | ISSN: | 0264410X 18732518 |
DOI: | 10.1016/j.vaccine.2020.06.007 |
Appears in Collections: | Elements Staff Publications |
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Schaefer et al 2020 COVID-19 Challenge Study Authors' Accepted Manuscript (002).docx | 45.62 kB | Microsoft Word XML | OPEN | Post-print | View/Download |
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