Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-020-65153-3
Title: Reference Ranges for Left Ventricular Curvedness and Curvedness-Based Functional Indices Using Cardiovascular Magnetic Resonance in Healthy Asian Subjects
Authors: Zhao, Xiaodan 
Teo, Soo-Kng
Zhong, Liang 
Leng, Shuang 
Zhang, Jun-Mei
Low, Ris
Allen, John 
Koh, Angela S 
Su, Yi
Tan, Ru-San 
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
PRESERVED EJECTION FRACTION
REGIONAL WALL CURVEDNESS
HEART-FAILURE
AUTOMATIC SEGMENTATION
NORMAL VALUES
FEATURE-TRACKING
AREA STRAIN
STRESS
SHAPE
ECHOCARDIOGRAPHY
Issue Date: 21-May-2020
Publisher: NATURE PUBLISHING GROUP
Citation: Zhao, Xiaodan, Teo, Soo-Kng, Zhong, Liang, Leng, Shuang, Zhang, Jun-Mei, Low, Ris, Allen, John, Koh, Angela S, Su, Yi, Tan, Ru-San (2020-05-21). Reference Ranges for Left Ventricular Curvedness and Curvedness-Based Functional Indices Using Cardiovascular Magnetic Resonance in Healthy Asian Subjects. SCIENTIFIC REPORTS 10 (1). ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-020-65153-3
Abstract: Curvature-based three-dimensional cardiovascular magnetic resonance (CMR) allows regional function characterization without an external spatial frame of reference. However, introduction of this modality into clinical practice is hampered by lack of reference values. We aim to establish normal ranges for 3D left ventricular (LV) regional parameters in relation to age and gender for 171 healthy subjects. LV geometrical reconstruction and automatic calculation of regional parameters were implemented by in-house software (CardioWerkz) using stacks of short-axis cine slices. Parameter normal ranges were stratified by gender and age categories (≤44, 45–64, 65–74 and 75–84 years). Our software had excellent intra- and inter-observer agreement. Ageing was significantly associated with increases in end-systolic (ES) curvedness (CES) and area strain (AS) with higher rates of increase in males, end-diastolic (ED) and ES wall thickness (WTED, WTES) with higher rates of increase in females, and reductions in ED and ES wall stress indices (σi,ED) with higher rates of increase in females. Females exhibited greater ED curvedness, CES, σi,ED and AS than males, but smaller WTED and WTES. Age × gender interaction was not observed for any parameter. This study establishes age and gender specific reference values for 3D LV regional parameters using CMR without additional image acquisition.
Source Title: SCIENTIFIC REPORTS
URI: https://scholarbank.nus.edu.sg/handle/10635/226680
ISSN: 20452322
DOI: 10.1038/s41598-020-65153-3
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