Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-020-65153-3
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dc.titleReference Ranges for Left Ventricular Curvedness and Curvedness-Based Functional Indices Using Cardiovascular Magnetic Resonance in Healthy Asian Subjects
dc.contributor.authorZhao, Xiaodan
dc.contributor.authorTeo, Soo-Kng
dc.contributor.authorZhong, Liang
dc.contributor.authorLeng, Shuang
dc.contributor.authorZhang, Jun-Mei
dc.contributor.authorLow, Ris
dc.contributor.authorAllen, John
dc.contributor.authorKoh, Angela S
dc.contributor.authorSu, Yi
dc.contributor.authorTan, Ru-San
dc.date.accessioned2022-06-08T00:54:14Z
dc.date.available2022-06-08T00:54:14Z
dc.date.issued2020-05-21
dc.identifier.citationZhao, Xiaodan, Teo, Soo-Kng, Zhong, Liang, Leng, Shuang, Zhang, Jun-Mei, Low, Ris, Allen, John, Koh, Angela S, Su, Yi, Tan, Ru-San (2020-05-21). Reference Ranges for Left Ventricular Curvedness and Curvedness-Based Functional Indices Using Cardiovascular Magnetic Resonance in Healthy Asian Subjects. SCIENTIFIC REPORTS 10 (1). ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-020-65153-3
dc.identifier.issn20452322
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/226680
dc.description.abstractCurvature-based three-dimensional cardiovascular magnetic resonance (CMR) allows regional function characterization without an external spatial frame of reference. However, introduction of this modality into clinical practice is hampered by lack of reference values. We aim to establish normal ranges for 3D left ventricular (LV) regional parameters in relation to age and gender for 171 healthy subjects. LV geometrical reconstruction and automatic calculation of regional parameters were implemented by in-house software (CardioWerkz) using stacks of short-axis cine slices. Parameter normal ranges were stratified by gender and age categories (≤44, 45–64, 65–74 and 75–84 years). Our software had excellent intra- and inter-observer agreement. Ageing was significantly associated with increases in end-systolic (ES) curvedness (CES) and area strain (AS) with higher rates of increase in males, end-diastolic (ED) and ES wall thickness (WTED, WTES) with higher rates of increase in females, and reductions in ED and ES wall stress indices (σi,ED) with higher rates of increase in females. Females exhibited greater ED curvedness, CES, σi,ED and AS than males, but smaller WTED and WTES. Age × gender interaction was not observed for any parameter. This study establishes age and gender specific reference values for 3D LV regional parameters using CMR without additional image acquisition.
dc.language.isoen
dc.publisherNATURE PUBLISHING GROUP
dc.sourceElements
dc.subjectScience & Technology
dc.subjectMultidisciplinary Sciences
dc.subjectScience & Technology - Other Topics
dc.subjectPRESERVED EJECTION FRACTION
dc.subjectREGIONAL WALL CURVEDNESS
dc.subjectHEART-FAILURE
dc.subjectAUTOMATIC SEGMENTATION
dc.subjectNORMAL VALUES
dc.subjectFEATURE-TRACKING
dc.subjectAREA STRAIN
dc.subjectSTRESS
dc.subjectSHAPE
dc.subjectECHOCARDIOGRAPHY
dc.typeArticle
dc.date.updated2022-06-07T06:15:51Z
dc.contributor.departmentDEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
dc.contributor.departmentDEPT OF PHYSICS
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1038/s41598-020-65153-3
dc.description.sourcetitleSCIENTIFIC REPORTS
dc.description.volume10
dc.description.issue1
dc.published.statePublished
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