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Title: Dysfunctional bronchial cilia are a feature of Chronic Obstructive Pulmonary Disease (COPD)
Authors: Biju Thomas 
Mariko Siyue Koh 
Chris O'Callaghan
Andrew Rutman
Rob Hirst
John Connolly 
Su Ying Low 
Ong Thun How 
Loo Chian Min 
Darren Wan Teck Lim 
Oon Lin Ean Lynette 
Qixian He
Oon Hoe Teoh 
Therese Lapperre 
Keywords: Chronic obstructive pulmonary disease
ciliary function
epithelial ultrastructure
Issue Date: 1-Sep-2021
Publisher: Taylor & Francis
Citation: Biju Thomas, Mariko Siyue Koh, Chris O'Callaghan, JOHN ALLEN, Andrew Rutman, Rob Hirst, John Connolly, Su Ying Low, Ong Thun How, Loo Chian Min, Darren Wan Teck Lim, Oon Lin Ean Lynette, Qixian He, Oon Hoe Teoh, Therese Lapperre (2021-09-01). Dysfunctional bronchial cilia are a feature of Chronic Obstructive Pulmonary Disease (COPD). COPD: Journal of Chronic Obstructive Pulmonary Disease 18 (06) : 657-663. ScholarBank@NUS Repository.
Abstract: Impaired mucociliary clearance may increase COPD exacerbation risk. We aimed to compare bronchial ciliary function and epithelial ultrastructure of COPD patients to healthy controls and explore its relationship to exacerbator phenotypes (frequent [FE] and infrequent [IFE] exacerbator). In this cross-sectional study, 16 COPD patients and 12 controls underwent bronchial brushings. Ciliary beat frequency (CBF) and dyskinesia index (DI; % of dyskinetic cilia) were assessed using digital high-speed video microscopy, and epithelial ultrastructure using transmission electron microscopy (TEM). Bronchial epithelium in COPD showed lower CBF and higher DI, compared to controls (median [IQR] CBF: 6.8 (6.1–7.2) Hz vs 8.5 (7.7–8.9) Hz, p<0.001 and DI: 73.8 (60.7–89.8) % vs 14.5 (11.2–16.9) %, p<0.001, respectively). This was true for FE and IFE phenotypes of COPD, which were similar in terms of bronchial CBF or DI. Subgroup analyses demonstrated lower CBF and higher DI in FE and IFE COPD phenotypes compared to controls, irrespective of smoking status. TEM showed more loss of cilia, extrusion of cells, cytoplasmic blebs and dead cells in COPD patients versus controls. Profound dysfunction of bronchial cilia is a feature of COPD irrespective of exacerbation phenotype and smoking status, which is likely to contribute to poor mucus clearance in COPD.
Source Title: COPD: Journal of Chronic Obstructive Pulmonary Disease
ISSN: 1541-2555
DOI: 10.1080/15412555.2021.1963695
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