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Title: Measurement properties of existing patient-reported outcome measures on medication adherence: Systematic review
Authors: Kwan, Y.H. 
Weng, S.D.
Fang Loh, D.H.
Phang, J.K.
Yi Oo, L.J.
Blalock, D.V.
Chew, Eng Hui
Yap, K.Z. 
Koon Tan, C.Y.
Yoon, S.
Fong, W. 
Østbye, T. 
Low, L.L. 
Bosworth, H.B.
Thumboo, J. 
Keywords: Medication adherence
Patient reported outcome measures
Reliability and validity
Systematic review
Issue Date: 2020
Publisher: JMIR Publications Inc.
Citation: Kwan, Y.H., Weng, S.D., Fang Loh, D.H., Phang, J.K., Yi Oo, L.J., Blalock, D.V., Chew, Eng Hui, Yap, K.Z., Koon Tan, C.Y., Yoon, S., Fong, W., Østbye, T., Low, L.L., Bosworth, H.B., Thumboo, J. (2020). Measurement properties of existing patient-reported outcome measures on medication adherence: Systematic review. Journal of Medical Internet Research 22 (10) : e19179. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Background: Medication adherence is essential for improving the health outcomes of patients. Various patient-reported outcome measures (PROMs) have been developed to measure medication adherence in patients. However, no study has summarized the psychometric properties of these PROMs to guide selection for use in clinical practice or research. Objective: This study aims to evaluate the quality of the PROMs used to measure medication adherence. Methods: This study was guided by the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines. Relevant articles were retrieved from the EMBASE, PubMed, Cochrane Library, Web of Science, and CINAHL (Cumulative Index to Nursing and Allied Health Literature) databases. The PROMs were then evaluated based on the COnsensus-based Standards for the selection of health Measurement Instruments (COSMIN) guidelines. Results: A total of 121 unique medication adherence PROMs from 214 studies were identified. Hypotheses testing for construct validity and internal consistency were the most frequently assessed measurement properties. PROMs with at least a moderate level of evidence for ?5 measurement properties include the Adherence Starts with Knowledge 20, Compliance Questionnaire-Rheumatology, General Medication Adherence Scale, Hill-Bone Scale, Immunosuppressant Therapy Barrier Scale, Medication Adherence Reasons Scale (MAR-Scale) revised, 5-item Medication Adherence Rating Scale (MARS-5), 9-item MARS (MARS-9), 4-item Morisky Medication Adherence Scale (MMAS-4), 8-item MMAS (MMAS-8), Self-efficacy for Appropriate Medication Adherence Scale, Satisfaction with Iron Chelation Therapy, Test of Adherence to Inhalers, and questionnaire by Voils. The MAR-Scale revised, MMAS-4, and MMAS-8 have been administered electronically. Conclusions: This study identified 121 PROMs for medication adherence and provided synthesized evidence for the measurement properties of these PROMs. The findings from this study may assist clinicians and researchers in selecting suitable PROMs to assess medication adherence. © Yu Heng Kwan, Si Dun Weng, Dionne Hui Fang Loh, Jie Kie Phang, Livia Jia Yi Oo, Dan V Blalock, Eng Hui Chew, Kai Zhen Yap, Corrinne Yong Koon Tan, Sungwon Yoon, Warren Fong, Truls Østbye, Lian Leng Low, Hayden Barry Bosworth, Julian Thumboo.
Source Title: Journal of Medical Internet Research
ISSN: 14388871
DOI: 10.2196/19179
Rights: Attribution 4.0 International
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