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|Title:||Retinal-detachment repair and vitreous-like-body reformation via a thermogelling polymer endotamponade||Authors:||LIU, Z
|Issue Date:||1-Jan-2019||Publisher:||Springer Nature||Citation:||LIU, Z, LIOW, SS, LAI, SL, ALLI-SHAIK, A, HOLDER, GE, PARIKH, BH, KRISHNAKUMAR, S, LI, Z, TAN, MJ, GUNARATNE, J, BARATHI, VA, HUNZIKER, W, LAKSHMINARAYANAN, R, TAN, CWT, CHEE, CK, ZHAO, P, LINGAM, G, LOH, XJ, SU, X (2019-01-01). Retinal-detachment repair and vitreous-like-body reformation via a thermogelling polymer endotamponade. Nature Biomedical Engineering. ScholarBank@NUS Repository. https://doi.org/10.1038/s41551-019-0382-7||Abstract:||© 2019, The Author(s), under exclusive licence to Springer Nature Limited. Internal-tamponade agents are crucial surgical adjuncts in vitreoretinal surgery. Clinically used endotamponade agents act through buoyancy forces, yet can result in prolonged post-operative positioning, temporary loss of vision, raised intra-ocular pressure, cataract formation or the need for additional removal surgery. Here, we describe a thermogelling polymer that provides an internal tamponade effect through surface tension and swelling counter-forces. We tested the long-term biocompatibility of the polymer endotamponade in rabbit vitrectomy models, and its surgical efficacy and biocompatibility in a non-human primate retinal-detachment model. We also show that, while the thermogel biodegrades during the three months following surgery, it promotes the reformation of a vitreous-like body that mimics the biophysical properties of the natural vitreous. The thermogelling endotamponade might serve as a long-term vitreous substitute.||Source Title:||Nature Biomedical Engineering||URI:||https://scholarbank.nus.edu.sg/handle/10635/155155||ISSN:||2157846X||DOI:||10.1038/s41551-019-0382-7|
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