Please use this identifier to cite or link to this item:
https://doi.org/10.1038/s41551-019-0382-7
DC Field | Value | |
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dc.title | Retinal-detachment repair and vitreous-like-body reformation via a thermogelling polymer endotamponade | |
dc.contributor.author | LIU, Z | |
dc.contributor.author | LIOW, SS | |
dc.contributor.author | LAI, SL | |
dc.contributor.author | ALLI-SHAIK, A | |
dc.contributor.author | HOLDER, GE | |
dc.contributor.author | PARIKH, BH | |
dc.contributor.author | KRISHNAKUMAR, S | |
dc.contributor.author | LI, Z | |
dc.contributor.author | TAN, MJ | |
dc.contributor.author | GUNARATNE, J | |
dc.contributor.author | BARATHI, VA | |
dc.contributor.author | HUNZIKER, W | |
dc.contributor.author | LAKSHMINARAYANAN, R | |
dc.contributor.author | TAN, CWT | |
dc.contributor.author | CHEE, CK | |
dc.contributor.author | ZHAO, P | |
dc.contributor.author | LINGAM, G | |
dc.contributor.author | LOH, XJ | |
dc.contributor.author | SU, X | |
dc.date.accessioned | 2019-06-04T04:02:18Z | |
dc.date.available | 2019-06-04T04:02:18Z | |
dc.date.issued | 2019-01-01 | |
dc.identifier.citation | LIU, Z, LIOW, SS, LAI, SL, ALLI-SHAIK, A, HOLDER, GE, PARIKH, BH, KRISHNAKUMAR, S, LI, Z, TAN, MJ, GUNARATNE, J, BARATHI, VA, HUNZIKER, W, LAKSHMINARAYANAN, R, TAN, CWT, CHEE, CK, ZHAO, P, LINGAM, G, LOH, XJ, SU, X (2019-01-01). Retinal-detachment repair and vitreous-like-body reformation via a thermogelling polymer endotamponade. Nature Biomedical Engineering. ScholarBank@NUS Repository. https://doi.org/10.1038/s41551-019-0382-7 | |
dc.identifier.issn | 2157846X | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/155155 | |
dc.description.abstract | © 2019, The Author(s), under exclusive licence to Springer Nature Limited. Internal-tamponade agents are crucial surgical adjuncts in vitreoretinal surgery. Clinically used endotamponade agents act through buoyancy forces, yet can result in prolonged post-operative positioning, temporary loss of vision, raised intra-ocular pressure, cataract formation or the need for additional removal surgery. Here, we describe a thermogelling polymer that provides an internal tamponade effect through surface tension and swelling counter-forces. We tested the long-term biocompatibility of the polymer endotamponade in rabbit vitrectomy models, and its surgical efficacy and biocompatibility in a non-human primate retinal-detachment model. We also show that, while the thermogel biodegrades during the three months following surgery, it promotes the reformation of a vitreous-like body that mimics the biophysical properties of the natural vitreous. The thermogelling endotamponade might serve as a long-term vitreous substitute. | |
dc.publisher | Springer Nature | |
dc.source | Elements | |
dc.type | Article | |
dc.date.updated | 2019-06-03T07:25:40Z | |
dc.contributor.department | ANATOMY | |
dc.contributor.department | CHEMISTRY | |
dc.contributor.department | MATERIALS SCIENCE AND ENGINEERING | |
dc.contributor.department | OPHTHALMOLOGY | |
dc.contributor.department | PHYSIOLOGY | |
dc.contributor.department | MECHANOBIOLOGY INSTITUTE | |
dc.contributor.department | NUS INDUSTRY LIAISON OFFICE | |
dc.description.doi | 10.1038/s41551-019-0382-7 | |
dc.description.sourcetitle | Nature Biomedical Engineering | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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hydrogel NBM Z.Liu et al 2019.pdf | 4.69 MB | Adobe PDF | CLOSED | Published |
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