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Title: Recombinant non-structural 1 (NS1) protein of dengue-2 virus interacts with human STAT3β protein
Authors: Chua, J.J.-E.
Bhuvanakantham, R. 
Chow, V.T.-K. 
Ng, M.-L. 
Keywords: Dengue virus
Human STAT3β protein
Non-structural 1 protein
Protein-protein interaction
Yeast 2-hybrid
Issue Date: 2005
Citation: Chua, J.J.-E., Bhuvanakantham, R., Chow, V.T.-K., Ng, M.-L. (2005). Recombinant non-structural 1 (NS1) protein of dengue-2 virus interacts with human STAT3β protein. Virus Research 112 (1-2) : 85-94. ScholarBank@NUS Repository.
Abstract: A combination of yeast two-hybrid library screening, co-immunoprecipitation and immunofluorescence microscopy demonstrated that dengue-2 virus non-structural 1 (NS1) protein can interact with an N-terminally truncated form of human STAT3β (ΔN40-STAT3β) protein. The NS1 protein interacted with the activated STAT3β protein in vesicle-like structures in the cell cytoplasm. In addition, transfection of dendritic cells with plasmid expressing NS1 protein also resulted in significant induction of tumor necrosis factor-α (TNFα) and interleukin-6 (IL-6). Since the STAT3β protein is an acute-phase response factor, its interaction with NS1 protein may influence the pathological changes observed in dengue fever, dengue hemorrhagic fever and dengue shock syndrome. © 2005 Elsevier B.V. All rights reserved.
Source Title: Virus Research
ISSN: 01681702
DOI: 10.1016/j.virusres.2005.03.025
Appears in Collections:Staff Publications

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