Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.virusres.2005.03.025
DC Field | Value | |
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dc.title | Recombinant non-structural 1 (NS1) protein of dengue-2 virus interacts with human STAT3β protein | |
dc.contributor.author | Chua, J.J.-E. | |
dc.contributor.author | Bhuvanakantham, R. | |
dc.contributor.author | Chow, V.T.-K. | |
dc.contributor.author | Ng, M.-L. | |
dc.date.accessioned | 2011-07-26T06:53:33Z | |
dc.date.available | 2011-07-26T06:53:33Z | |
dc.date.issued | 2005 | |
dc.identifier.citation | Chua, J.J.-E., Bhuvanakantham, R., Chow, V.T.-K., Ng, M.-L. (2005). Recombinant non-structural 1 (NS1) protein of dengue-2 virus interacts with human STAT3β protein. Virus Research 112 (1-2) : 85-94. ScholarBank@NUS Repository. https://doi.org/10.1016/j.virusres.2005.03.025 | |
dc.identifier.issn | 01681702 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/24716 | |
dc.description.abstract | A combination of yeast two-hybrid library screening, co-immunoprecipitation and immunofluorescence microscopy demonstrated that dengue-2 virus non-structural 1 (NS1) protein can interact with an N-terminally truncated form of human STAT3β (ΔN40-STAT3β) protein. The NS1 protein interacted with the activated STAT3β protein in vesicle-like structures in the cell cytoplasm. In addition, transfection of dendritic cells with plasmid expressing NS1 protein also resulted in significant induction of tumor necrosis factor-α (TNFα) and interleukin-6 (IL-6). Since the STAT3β protein is an acute-phase response factor, its interaction with NS1 protein may influence the pathological changes observed in dengue fever, dengue hemorrhagic fever and dengue shock syndrome. © 2005 Elsevier B.V. All rights reserved. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.virusres.2005.03.025 | |
dc.source | Scopus | |
dc.subject | Dengue virus | |
dc.subject | Flaviviruses | |
dc.subject | Human STAT3β protein | |
dc.subject | Non-structural 1 protein | |
dc.subject | Protein-protein interaction | |
dc.subject | Yeast 2-hybrid | |
dc.type | Article | |
dc.contributor.department | MICROBIOLOGY | |
dc.description.doi | 10.1016/j.virusres.2005.03.025 | |
dc.description.sourcetitle | Virus Research | |
dc.description.volume | 112 | |
dc.description.issue | 1-2 | |
dc.description.page | 85-94 | |
dc.identifier.isiut | 000231004300011 | |
Appears in Collections: | Staff Publications |
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