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Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.virusres.2005.03.025
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dc.titleRecombinant non-structural 1 (NS1) protein of dengue-2 virus interacts with human STAT3β protein
dc.contributor.authorChua, J.J.-E.
dc.contributor.authorBhuvanakantham, R.
dc.contributor.authorChow, V.T.-K.
dc.contributor.authorNg, M.-L.
dc.date.accessioned2011-07-26T06:53:33Z
dc.date.available2011-07-26T06:53:33Z
dc.date.issued2005
dc.identifier.citationChua, J.J.-E., Bhuvanakantham, R., Chow, V.T.-K., Ng, M.-L. (2005). Recombinant non-structural 1 (NS1) protein of dengue-2 virus interacts with human STAT3β protein. Virus Research 112 (1-2) : 85-94. ScholarBank@NUS Repository. https://doi.org/10.1016/j.virusres.2005.03.025
dc.identifier.issn01681702
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/24716
dc.description.abstractA combination of yeast two-hybrid library screening, co-immunoprecipitation and immunofluorescence microscopy demonstrated that dengue-2 virus non-structural 1 (NS1) protein can interact with an N-terminally truncated form of human STAT3β (ΔN40-STAT3β) protein. The NS1 protein interacted with the activated STAT3β protein in vesicle-like structures in the cell cytoplasm. In addition, transfection of dendritic cells with plasmid expressing NS1 protein also resulted in significant induction of tumor necrosis factor-α (TNFα) and interleukin-6 (IL-6). Since the STAT3β protein is an acute-phase response factor, its interaction with NS1 protein may influence the pathological changes observed in dengue fever, dengue hemorrhagic fever and dengue shock syndrome. © 2005 Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.virusres.2005.03.025
dc.sourceScopus
dc.subjectDengue virus
dc.subjectFlaviviruses
dc.subjectHuman STAT3β protein
dc.subjectNon-structural 1 protein
dc.subjectProtein-protein interaction
dc.subjectYeast 2-hybrid
dc.typeArticle
dc.contributor.departmentMICROBIOLOGY
dc.description.doi10.1016/j.virusres.2005.03.025
dc.description.sourcetitleVirus Research
dc.description.volume112
dc.description.issue1-2
dc.description.page85-94
dc.identifier.isiut000231004300011
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