Please use this identifier to cite or link to this item:
|Title:||Recombinant non-structural 1 (NS1) protein of dengue-2 virus interacts with human STAT3β protein|
Human STAT3β protein
Non-structural 1 protein
|Citation:||Chua, J.J.-E., Bhuvanakantham, R., Chow, V.T.-K., Ng, M.-L. (2005). Recombinant non-structural 1 (NS1) protein of dengue-2 virus interacts with human STAT3β protein. Virus Research 112 (1-2) : 85-94. ScholarBank@NUS Repository. https://doi.org/10.1016/j.virusres.2005.03.025|
|Abstract:||A combination of yeast two-hybrid library screening, co-immunoprecipitation and immunofluorescence microscopy demonstrated that dengue-2 virus non-structural 1 (NS1) protein can interact with an N-terminally truncated form of human STAT3β (ΔN40-STAT3β) protein. The NS1 protein interacted with the activated STAT3β protein in vesicle-like structures in the cell cytoplasm. In addition, transfection of dendritic cells with plasmid expressing NS1 protein also resulted in significant induction of tumor necrosis factor-α (TNFα) and interleukin-6 (IL-6). Since the STAT3β protein is an acute-phase response factor, its interaction with NS1 protein may influence the pathological changes observed in dengue fever, dengue hemorrhagic fever and dengue shock syndrome. © 2005 Elsevier B.V. All rights reserved.|
|Source Title:||Virus Research|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Dec 12, 2018
WEB OF SCIENCETM
checked on Dec 3, 2018
checked on Nov 24, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.