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https://doi.org/10.1016/j.virusres.2005.03.025
| Title: | Recombinant non-structural 1 (NS1) protein of dengue-2 virus interacts with human STAT3β protein | Authors: | Chua, J.J.-E. Bhuvanakantham, R. Chow, V.T.-K. Ng, M.-L. |
Keywords: | Dengue virus Flaviviruses Human STAT3β protein Non-structural 1 protein Protein-protein interaction Yeast 2-hybrid |
Issue Date: | 2005 | Citation: | Chua, J.J.-E., Bhuvanakantham, R., Chow, V.T.-K., Ng, M.-L. (2005). Recombinant non-structural 1 (NS1) protein of dengue-2 virus interacts with human STAT3β protein. Virus Research 112 (1-2) : 85-94. ScholarBank@NUS Repository. https://doi.org/10.1016/j.virusres.2005.03.025 | Abstract: | A combination of yeast two-hybrid library screening, co-immunoprecipitation and immunofluorescence microscopy demonstrated that dengue-2 virus non-structural 1 (NS1) protein can interact with an N-terminally truncated form of human STAT3β (ΔN40-STAT3β) protein. The NS1 protein interacted with the activated STAT3β protein in vesicle-like structures in the cell cytoplasm. In addition, transfection of dendritic cells with plasmid expressing NS1 protein also resulted in significant induction of tumor necrosis factor-α (TNFα) and interleukin-6 (IL-6). Since the STAT3β protein is an acute-phase response factor, its interaction with NS1 protein may influence the pathological changes observed in dengue fever, dengue hemorrhagic fever and dengue shock syndrome. © 2005 Elsevier B.V. All rights reserved. | Source Title: | Virus Research | URI: | http://scholarbank.nus.edu.sg/handle/10635/24716 | ISSN: | 01681702 | DOI: | 10.1016/j.virusres.2005.03.025 |
| Appears in Collections: | Staff Publications |
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