Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41577-020-0311-8
Title: The trinity of COVID-19: immunity, inflammation and intervention
Authors: Tay, Matthew Zirui
Poh, Chek Meng
Renia, Laurent 
MacAry, Paul A 
Ng, Lisa FP 
Keywords: Science & Technology
Life Sciences & Biomedicine
Immunology
ACUTE RESPIRATORY SYNDROME
CORONAVIRUS SARS-COV
T-CELL RESPONSES
NEUTRALIZING ANTIBODY-RESPONSE
CONVALESCENT PLASMA
SPIKE PROTEIN
MONOCLONAL-ANTIBODY
LYMPHOCYTE SUBSETS
ACE2 RECEPTOR
VIRAL LOAD
Issue Date: Jun-2020
Publisher: NATURE PORTFOLIO
Citation: Tay, Matthew Zirui, Poh, Chek Meng, Renia, Laurent, MacAry, Paul A, Ng, Lisa FP (2020-06). The trinity of COVID-19: immunity, inflammation and intervention. NATURE REVIEWS IMMUNOLOGY 20 (6) : 363-374. ScholarBank@NUS Repository. https://doi.org/10.1038/s41577-020-0311-8
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic. Alongside investigations into the virology of SARS-CoV-2, understanding the fundamental physiological and immunological processes underlying the clinical manifestations of COVID-19 is vital for the identification and rational design of effective therapies. Here, we provide an overview of the pathophysiology of SARS-CoV-2 infection. We describe the interaction of SARS-CoV-2 with the immune system and the subsequent contribution of dysfunctional immune responses to disease progression. From nascent reports describing SARS-CoV-2, we make inferences on the basis of the parallel pathophysiological and immunological features of the other human coronaviruses targeting the lower respiratory tract — severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). Finally, we highlight the implications of these approaches for potential therapeutic interventions that target viral infection and/or immunoregulation.
Source Title: NATURE REVIEWS IMMUNOLOGY
URI: https://scholarbank.nus.edu.sg/handle/10635/239500
ISSN: 1474-1733
1474-1741
DOI: 10.1038/s41577-020-0311-8
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