Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41577-020-0311-8
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dc.titleThe trinity of COVID-19: immunity, inflammation and intervention
dc.contributor.authorTay, Matthew Zirui
dc.contributor.authorPoh, Chek Meng
dc.contributor.authorRenia, Laurent
dc.contributor.authorMacAry, Paul A
dc.contributor.authorNg, Lisa FP
dc.date.accessioned2023-05-18T08:41:33Z
dc.date.available2023-05-18T08:41:33Z
dc.date.issued2020-06
dc.identifier.citationTay, Matthew Zirui, Poh, Chek Meng, Renia, Laurent, MacAry, Paul A, Ng, Lisa FP (2020-06). The trinity of COVID-19: immunity, inflammation and intervention. NATURE REVIEWS IMMUNOLOGY 20 (6) : 363-374. ScholarBank@NUS Repository. https://doi.org/10.1038/s41577-020-0311-8
dc.identifier.issn1474-1733
dc.identifier.issn1474-1741
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/239500
dc.description.abstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic. Alongside investigations into the virology of SARS-CoV-2, understanding the fundamental physiological and immunological processes underlying the clinical manifestations of COVID-19 is vital for the identification and rational design of effective therapies. Here, we provide an overview of the pathophysiology of SARS-CoV-2 infection. We describe the interaction of SARS-CoV-2 with the immune system and the subsequent contribution of dysfunctional immune responses to disease progression. From nascent reports describing SARS-CoV-2, we make inferences on the basis of the parallel pathophysiological and immunological features of the other human coronaviruses targeting the lower respiratory tract — severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). Finally, we highlight the implications of these approaches for potential therapeutic interventions that target viral infection and/or immunoregulation.
dc.language.isoen
dc.publisherNATURE PORTFOLIO
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectImmunology
dc.subjectACUTE RESPIRATORY SYNDROME
dc.subjectCORONAVIRUS SARS-COV
dc.subjectT-CELL RESPONSES
dc.subjectNEUTRALIZING ANTIBODY-RESPONSE
dc.subjectCONVALESCENT PLASMA
dc.subjectSPIKE PROTEIN
dc.subjectMONOCLONAL-ANTIBODY
dc.subjectLYMPHOCYTE SUBSETS
dc.subjectACE2 RECEPTOR
dc.subjectVIRAL LOAD
dc.typeReview
dc.date.updated2023-05-18T03:51:59Z
dc.contributor.departmentBIOCHEMISTRY
dc.contributor.departmentMICROBIOLOGY AND IMMUNOLOGY
dc.description.doi10.1038/s41577-020-0311-8
dc.description.sourcetitleNATURE REVIEWS IMMUNOLOGY
dc.description.volume20
dc.description.issue6
dc.description.page363-374
dc.published.statePublished
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