Please use this identifier to cite or link to this item: https://doi.org/10.1515/jpm-2020-0298
Title: Risk factors for pregnancy-associated venous thromboembolism in Singapore
Authors: Jaya-Bodestyne, Sandra Lynn
Lee, Lai Heng
Tan, Lay Kok
Tan, Kok Hian 
Østbye, T. 
Malhotra, Rahul 
Allen, John 
Tan, Sophie Seine Xuan
Tan, Melinda Si Yun 
Ng, Lawrence Cheng Kiat
Yong, Yang
Tan, Thiam Chye 
Keywords: postpartum
pregnancy
risk factors
venous thromboembolism
Issue Date: 5-Sep-2020
Publisher: De Gruyter Open Ltd
Citation: Jaya-Bodestyne, Sandra Lynn, Lee, Lai Heng, Tan, Lay Kok, Tan, Kok Hian, Østbye, T., Malhotra, Rahul, Allen, John, Tan, Sophie Seine Xuan, Tan, Melinda Si Yun, Ng, Lawrence Cheng Kiat, Yong, Yang, Tan, Thiam Chye (2020-09-05). Risk factors for pregnancy-associated venous thromboembolism in Singapore. Journal of Perinatal Medicine 49 (2) : 153-158. ScholarBank@NUS Repository. https://doi.org/10.1515/jpm-2020-0298
Rights: Attribution 4.0 International
Abstract: Pregnancy-associated venous thromboembolism (VTE), including deep venous thrombosis (DVT) and pulmonary embolism (PE), is associated with increased risk of maternal mortality and morbidity. This study aimed to assess potential risk factors for pregnancy-associated VTE. In this case-control study, women with pregnancy-associated VTE were identified via International Classification of Diseases codes and included if they had been objectively diagnosed with VTE during pregnancy or within six weeks postpartum, from 2004 to 2016, at KK Women's and Children's Hospital or Singapore General Hospital in Singapore. Controls, i.e. pregnant women without VTE, were selected from a prospective longitudinal study. The odds ratio (OR) for VTE was computed for a range of maternal and obstetric factors. From 2004 to 2016, 89 cases of pregnancy-associated VTE and 926 controls were identifed and analysed using logistic regression. The most significant risk factors for pregnancy-associated VTE were smoking (OR 5.44, p=0.0002) and preterm delivery (OR 5.06, p=0.023). Malay race, multiparity, non-O blood group and caesarean section, were also identified to be of higher risk. These risk factors should be useful in the development of thromboprophylaxis strategies for pregnancy and the postpartum period, especially in Singapore. © 2020 Sandra Lynn Jaya-Bodestyne et al., published by De Gruyter, Berlin/Boston.
Source Title: Journal of Perinatal Medicine
URI: https://scholarbank.nus.edu.sg/handle/10635/233871
ISSN: 0300-5577
DOI: 10.1515/jpm-2020-0298
Rights: Attribution 4.0 International
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