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Title: Stool metagenome analysis of patients with Klebsiella pneumoniae liver abscess and their domestic partners
Authors: Molton, James S. 
Lee, I. Russel
Bertrand, Denis
Ding, Ying
Kalimuddin, Shirin 
Lye, David C. 
Nagarajan, Niranjan 
Gan, Yunn-Hwen 
Archuleta, Sophia 
Keywords: Genomics
Klebsiella pneumoniae
Liver abscess
Issue Date: 1-Jun-2021
Publisher: Elsevier B.V.
Citation: Molton, James S., Lee, I. Russel, Bertrand, Denis, Ding, Ying, Kalimuddin, Shirin, Lye, David C., Nagarajan, Niranjan, Gan, Yunn-Hwen, Archuleta, Sophia (2021-06-01). Stool metagenome analysis of patients with Klebsiella pneumoniae liver abscess and their domestic partners. International Journal of Infectious Diseases 107 : 1-Apr. ScholarBank@NUS Repository.
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Abstract: Objectives: Hypermucoviscous Klebsiella pneumoniae is an emerging cause of community-acquired liver abscess. The aim of this study was to investigate whether hypermucoviscous strains could be shared among households. Methods: The clinical K. pneumoniae isolates from a cohort of 24 patients with Klebsiella liver abscess were genotyped, and the stool metagenomes of the index patients and their cohabiting domestic partners were analyzed. Results: K. pneumoniae was identified in 33% of index patient stools, and one index patient's clinical isolate was identified in their domestic partner's stool. Conclusions: This could represent a transmission event or could represent exposure to a common environmental source. © 2021 The Authors
Source Title: International Journal of Infectious Diseases
ISSN: 1201-9712
DOI: 10.1016/j.ijid.2021.04.012
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
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