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Title: Fucoidan but not 2′-fucosyllactose inhibits human norovirus replication in zebrafish larvae
Authors: Tan, Malcolm Turk Hsern
Li, Yan 
Eshaghi Gorji, M.
Gong, Zhiyuan 
Li, Dan 
Keywords: 2′-fucosyllactose
Issue Date: 11-Mar-2021
Publisher: MDPI AG
Citation: Tan, Malcolm Turk Hsern, Li, Yan, Eshaghi Gorji, M., Gong, Zhiyuan, Li, Dan (2021-03-11). Fucoidan but not 2′-fucosyllactose inhibits human norovirus replication in zebrafish larvae. Viruses 13 (3) : 461. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Human noroviruses (hNoVs) cause heavy disease burden worldwide and there is no clinically approved vaccination or antiviral hitherto. In this study, with the use of a zebrafish larva in vivo platform, we investigated the anti-hNoV potentials of fucoidan (from brown algae Fucus vesiculosus) and 2′-Fucosyllactose (2′-FL). As a result, although both fucoidan and 2′-FL were able to block hNoV GII.4 virus-like particle (VLPs) from binding to type A saliva as expected, only fucoidan, but not 2′-FL, was able to inhibit the replication of hNoV GII.P16-GII.4 in zebrafish larvae, indicating the possible needs of higher molecular weights for fucosylated carbohydrates to exert anti-hNoV effect. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: Viruses
ISSN: 1999-4915
DOI: 10.3390/v13030461
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications

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