Please use this identifier to cite or link to this item:
https://doi.org/10.3390/v13030461
Title: | Fucoidan but not 2′-fucosyllactose inhibits human norovirus replication in zebrafish larvae | Authors: | Tan, Malcolm Turk Hsern Li, Yan Eshaghi Gorji, M. Gong, Zhiyuan Li, Dan |
Keywords: | 2′-fucosyllactose Antiviral Fucoidan Norovirus |
Issue Date: | 11-Mar-2021 | Publisher: | MDPI AG | Citation: | Tan, Malcolm Turk Hsern, Li, Yan, Eshaghi Gorji, M., Gong, Zhiyuan, Li, Dan (2021-03-11). Fucoidan but not 2′-fucosyllactose inhibits human norovirus replication in zebrafish larvae. Viruses 13 (3) : 461. ScholarBank@NUS Repository. https://doi.org/10.3390/v13030461 | Rights: | Attribution 4.0 International | Abstract: | Human noroviruses (hNoVs) cause heavy disease burden worldwide and there is no clinically approved vaccination or antiviral hitherto. In this study, with the use of a zebrafish larva in vivo platform, we investigated the anti-hNoV potentials of fucoidan (from brown algae Fucus vesiculosus) and 2′-Fucosyllactose (2′-FL). As a result, although both fucoidan and 2′-FL were able to block hNoV GII.4 virus-like particle (VLPs) from binding to type A saliva as expected, only fucoidan, but not 2′-FL, was able to inhibit the replication of hNoV GII.P16-GII.4 in zebrafish larvae, indicating the possible needs of higher molecular weights for fucosylated carbohydrates to exert anti-hNoV effect. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | Source Title: | Viruses | URI: | https://scholarbank.nus.edu.sg/handle/10635/232125 | ISSN: | 1999-4915 | DOI: | 10.3390/v13030461 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
10_3390_v13030461.pdf | 738.16 kB | Adobe PDF | OPEN | None | View/Download |
This item is licensed under a Creative Commons License