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https://doi.org/10.3390/v13030461
DC Field | Value | |
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dc.title | Fucoidan but not 2′-fucosyllactose inhibits human norovirus replication in zebrafish larvae | |
dc.contributor.author | Tan, Malcolm Turk Hsern | |
dc.contributor.author | Li, Yan | |
dc.contributor.author | Eshaghi Gorji, M. | |
dc.contributor.author | Gong, Zhiyuan | |
dc.contributor.author | Li, Dan | |
dc.date.accessioned | 2022-10-11T08:01:42Z | |
dc.date.available | 2022-10-11T08:01:42Z | |
dc.date.issued | 2021-03-11 | |
dc.identifier.citation | Tan, Malcolm Turk Hsern, Li, Yan, Eshaghi Gorji, M., Gong, Zhiyuan, Li, Dan (2021-03-11). Fucoidan but not 2′-fucosyllactose inhibits human norovirus replication in zebrafish larvae. Viruses 13 (3) : 461. ScholarBank@NUS Repository. https://doi.org/10.3390/v13030461 | |
dc.identifier.issn | 1999-4915 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/232125 | |
dc.description.abstract | Human noroviruses (hNoVs) cause heavy disease burden worldwide and there is no clinically approved vaccination or antiviral hitherto. In this study, with the use of a zebrafish larva in vivo platform, we investigated the anti-hNoV potentials of fucoidan (from brown algae Fucus vesiculosus) and 2′-Fucosyllactose (2′-FL). As a result, although both fucoidan and 2′-FL were able to block hNoV GII.4 virus-like particle (VLPs) from binding to type A saliva as expected, only fucoidan, but not 2′-FL, was able to inhibit the replication of hNoV GII.P16-GII.4 in zebrafish larvae, indicating the possible needs of higher molecular weights for fucosylated carbohydrates to exert anti-hNoV effect. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | |
dc.publisher | MDPI AG | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Scopus OA2021 | |
dc.subject | 2′-fucosyllactose | |
dc.subject | Antiviral | |
dc.subject | Fucoidan | |
dc.subject | Norovirus | |
dc.type | Article | |
dc.contributor.department | BIOLOGICAL SCIENCES | |
dc.contributor.department | FOOD SCIENCE & TECHNOLOGY | |
dc.description.doi | 10.3390/v13030461 | |
dc.description.sourcetitle | Viruses | |
dc.description.volume | 13 | |
dc.description.issue | 3 | |
dc.description.page | 461 | |
Appears in Collections: | Staff Publications Elements |
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