Please use this identifier to cite or link to this item: https://doi.org/10.1097/HJH.0000000000003134
Title: Associations of maternal periconceptional alcohol consumption with offspring prehypertension/hypertension at age 6 years: the Growing Up in Singapore Towards healthy Outcomes prospective mother-offspring cohort study
Authors: Sadananthan, Suresh Anand 
Michael, Navin
Tint, Mya Thway 
Thirumurugan, Kashthuri
Yuan, Wen Lun 
Ong, Yi Ying 
Law, Evelyn 
Choo, Jonathan 
Ling, Lieng Hsi 
Shek, Lynette 
Fabian, Yap 
Tan, Kok Hian 
Vickers, Mark
Godfrey, Keith M
Gluckman, Peter D
Chong, Yap Seng 
Fortier, Marielle 
Lee, Yung Seng 
Eriksson, Johan G
Chan, Shiao-Yng
Moritz, Karen
Velan, S Sendhil
Wlodek, Mary E
Keywords: Science & Technology
Life Sciences & Biomedicine
Peripheral Vascular Disease
Cardiovascular System & Cardiology
hypertension
kidney
MRI
metabolic syndrome score
periconceptional alcohol consumption
BLOOD-PRESSURE
CARDIOVASCULAR RISK
ARTERIAL STIFFNESS
YOUNG ADULTHOOD
BIRTH OUTCOMES
EXPOSURE
PREGNANCY
CHILDHOOD
GROWTH
HYPERTENSION
Issue Date: 1-Jun-2022
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Citation: Sadananthan, Suresh Anand, Michael, Navin, Tint, Mya Thway, Thirumurugan, Kashthuri, Yuan, Wen Lun, Ong, Yi Ying, Law, Evelyn, Choo, Jonathan, Ling, Lieng Hsi, Shek, Lynette, Fabian, Yap, Tan, Kok Hian, Vickers, Mark, Godfrey, Keith M, Gluckman, Peter D, Chong, Yap Seng, Fortier, Marielle, Lee, Yung Seng, Eriksson, Johan G, Chan, Shiao-Yng, Moritz, Karen, Velan, S Sendhil, Wlodek, Mary E (2022-06-01). Associations of maternal periconceptional alcohol consumption with offspring prehypertension/hypertension at age 6 years: the Growing Up in Singapore Towards healthy Outcomes prospective mother-offspring cohort study. JOURNAL OF HYPERTENSION 40 (6) : 1212-1222. ScholarBank@NUS Repository. https://doi.org/10.1097/HJH.0000000000003134
Abstract: OBJECTIVE: To evaluate the relationship of the levels of maternal alcohol consumption during the 1 year before pregnancy recognition with childhood cardiorenal, metabolic, and neurocognitive health. METHODS: In 1106 women and their children from the Growing Up in Singapore Towards healthy Outcomes mother-offspring cohort, quantity of maternal alcohol consumption in the 12 months prior to pregnancy recognition was categorized as high (≥75th percentile: 1.9 g/day), low (<1.9 g/day), and none, and frequency of alcohol consumption was categorized as high (≥2-3 times/week), low (<2-3 times/week), and none. Offspring MRI-based abdominal fat depot, kidney, and brain volumes, blood pressure, metabolic syndrome score, and cognitive intelligence scores were assessed. Child prehypertension/hypertension at age 6 years was defined using a simplified pediatric threshold of 110/70 mmHg. RESULTS: The average maternal alcohol consumption in the year prior to pregnancy recognition was 2.5 g/day, which is lower than the daily maximal limit of one standard drink (10 g) recommended for women by Singapore's Ministry of Health. After adjusting for participant characteristics, alcohol consumption at least 1.9 g/day was associated with over two-fold higher risk (risk ratio = 2.18, P = 0.013) of child prehypertension and 15% greater kidney growth between early infancy and age 6 years (P = 0.040) compared with abstinence. Alcohol consumption was not associated with metabolic and neurocognitive health at age 6-7 years. The associations with high frequency of alcohol consumption were concordant with those obtained for quantity of alcohol consumption. CONCLUSION: Maternal self-reported alcohol consumption at least 1.9 g/day prior to pregnancy recognition was associated with increased risk of child prehypertension and rapid kidney growth. Our findings highlight the potential detrimental effects of low periconceptional alcohol consumption, below national guidelines on offspring cardiorenal health.
Source Title: JOURNAL OF HYPERTENSION
URI: https://scholarbank.nus.edu.sg/handle/10635/228782
ISSN: 02636352
14735598
DOI: 10.1097/HJH.0000000000003134
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