Please use this identifier to cite or link to this item: https://doi.org/10.1097/HJH.0000000000003134
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dc.titleAssociations of maternal periconceptional alcohol consumption with offspring prehypertension/hypertension at age 6 years: the Growing Up in Singapore Towards healthy Outcomes prospective mother-offspring cohort study
dc.contributor.authorSadananthan, Suresh Anand
dc.contributor.authorMichael, Navin
dc.contributor.authorTint, Mya Thway
dc.contributor.authorThirumurugan, Kashthuri
dc.contributor.authorYuan, Wen Lun
dc.contributor.authorOng, Yi Ying
dc.contributor.authorLaw, Evelyn
dc.contributor.authorChoo, Jonathan
dc.contributor.authorLing, Lieng Hsi
dc.contributor.authorShek, Lynette
dc.contributor.authorFabian, Yap
dc.contributor.authorTan, Kok Hian
dc.contributor.authorVickers, Mark
dc.contributor.authorGodfrey, Keith M
dc.contributor.authorGluckman, Peter D
dc.contributor.authorChong, Yap Seng
dc.contributor.authorFortier, Marielle
dc.contributor.authorLee, Yung Seng
dc.contributor.authorEriksson, Johan G
dc.contributor.authorChan, Shiao-Yng
dc.contributor.authorMoritz, Karen
dc.contributor.authorVelan, S Sendhil
dc.contributor.authorWlodek, Mary E
dc.date.accessioned2022-07-18T08:20:44Z
dc.date.available2022-07-18T08:20:44Z
dc.date.issued2022-06-01
dc.identifier.citationSadananthan, Suresh Anand, Michael, Navin, Tint, Mya Thway, Thirumurugan, Kashthuri, Yuan, Wen Lun, Ong, Yi Ying, Law, Evelyn, Choo, Jonathan, Ling, Lieng Hsi, Shek, Lynette, Fabian, Yap, Tan, Kok Hian, Vickers, Mark, Godfrey, Keith M, Gluckman, Peter D, Chong, Yap Seng, Fortier, Marielle, Lee, Yung Seng, Eriksson, Johan G, Chan, Shiao-Yng, Moritz, Karen, Velan, S Sendhil, Wlodek, Mary E (2022-06-01). Associations of maternal periconceptional alcohol consumption with offspring prehypertension/hypertension at age 6 years: the Growing Up in Singapore Towards healthy Outcomes prospective mother-offspring cohort study. JOURNAL OF HYPERTENSION 40 (6) : 1212-1222. ScholarBank@NUS Repository. https://doi.org/10.1097/HJH.0000000000003134
dc.identifier.issn02636352
dc.identifier.issn14735598
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/228782
dc.description.abstractOBJECTIVE: To evaluate the relationship of the levels of maternal alcohol consumption during the 1 year before pregnancy recognition with childhood cardiorenal, metabolic, and neurocognitive health. METHODS: In 1106 women and their children from the Growing Up in Singapore Towards healthy Outcomes mother-offspring cohort, quantity of maternal alcohol consumption in the 12 months prior to pregnancy recognition was categorized as high (≥75th percentile: 1.9 g/day), low (<1.9 g/day), and none, and frequency of alcohol consumption was categorized as high (≥2-3 times/week), low (<2-3 times/week), and none. Offspring MRI-based abdominal fat depot, kidney, and brain volumes, blood pressure, metabolic syndrome score, and cognitive intelligence scores were assessed. Child prehypertension/hypertension at age 6 years was defined using a simplified pediatric threshold of 110/70 mmHg. RESULTS: The average maternal alcohol consumption in the year prior to pregnancy recognition was 2.5 g/day, which is lower than the daily maximal limit of one standard drink (10 g) recommended for women by Singapore's Ministry of Health. After adjusting for participant characteristics, alcohol consumption at least 1.9 g/day was associated with over two-fold higher risk (risk ratio = 2.18, P = 0.013) of child prehypertension and 15% greater kidney growth between early infancy and age 6 years (P = 0.040) compared with abstinence. Alcohol consumption was not associated with metabolic and neurocognitive health at age 6-7 years. The associations with high frequency of alcohol consumption were concordant with those obtained for quantity of alcohol consumption. CONCLUSION: Maternal self-reported alcohol consumption at least 1.9 g/day prior to pregnancy recognition was associated with increased risk of child prehypertension and rapid kidney growth. Our findings highlight the potential detrimental effects of low periconceptional alcohol consumption, below national guidelines on offspring cardiorenal health.
dc.language.isoen
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectPeripheral Vascular Disease
dc.subjectCardiovascular System & Cardiology
dc.subjecthypertension
dc.subjectkidney
dc.subjectMRI
dc.subjectmetabolic syndrome score
dc.subjectpericonceptional alcohol consumption
dc.subjectBLOOD-PRESSURE
dc.subjectCARDIOVASCULAR RISK
dc.subjectARTERIAL STIFFNESS
dc.subjectYOUNG ADULTHOOD
dc.subjectBIRTH OUTCOMES
dc.subjectEXPOSURE
dc.subjectPREGNANCY
dc.subjectCHILDHOOD
dc.subjectGROWTH
dc.subjectHYPERTENSION
dc.typeArticle
dc.date.updated2022-07-15T18:13:41Z
dc.contributor.departmentDEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
dc.contributor.departmentDEAN'S OFFICE (MEDICINE)
dc.contributor.departmentDEPT OF MEDICINE
dc.contributor.departmentDEPT OF OBSTETRICS & GYNAECOLOGY
dc.contributor.departmentDEPT OF PAEDIATRICS
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1097/HJH.0000000000003134
dc.description.sourcetitleJOURNAL OF HYPERTENSION
dc.description.volume40
dc.description.issue6
dc.description.page1212-1222
dc.published.statePublished
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