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https://doi.org/10.1016/j.tem.2021.11.003
| Title: | Alpha-Ketoglutarate dietary supplementation to improve health in humans | Authors: | Gyanwali, Bibek Lim, Zi Xiang Soh, Janjira Lim, Clarissa Guan, Shou Ping Goh, Jorming Maier, Andrea B Kennedy, Brian K |
Keywords: | Science & Technology Life Sciences & Biomedicine Endocrinology & Metabolism DOUBLE-BLIND TRIAL OXIDATIVE STRESS CALORIC RESTRICTION PROTEIN-SYNTHESIS BRAIN METABOLISM SODIUM-SALT AMINO-ACID LIFE-SPAN PLASMA HYPOXIA |
Issue Date: | 1-Feb-2022 | Publisher: | ELSEVIER SCIENCE LONDON | Citation: | Gyanwali, Bibek, Lim, Zi Xiang, Soh, Janjira, Lim, Clarissa, Guan, Shou Ping, Goh, Jorming, Maier, Andrea B, Kennedy, Brian K (2022-02-01). Alpha-Ketoglutarate dietary supplementation to improve health in humans. TRENDS IN ENDOCRINOLOGY AND METABOLISM 33 (2) : 136-146. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tem.2021.11.003 | Abstract: | Alpha-ketoglutarate (AKG) is an intermediate in the Krebs cycle involved in various metabolic and cellular pathways. As an antioxidant, AKG interferes in nitrogen and ammonia balance, and affects epigenetic and immune regulation. These pleiotropic functions of AKG suggest it may also extend human healthspan. Recent studies in worms and mice support this concept. A few studies published in the 1980s and 1990s in humans suggested the potential benefits of AKG in muscle growth, wound healing, and in promoting faster recovery after surgery. So far there are no recently published studies demonstrating the role of AKG in treating aging and age-related diseases; hence, further clinical studies are required to better understand the role of AKG in humans. This review will discuss the regulatory role of AKG in aging, as well as its potential therapeutic use in humans to treat age-related diseases. | Source Title: | TRENDS IN ENDOCRINOLOGY AND METABOLISM | URI: | https://scholarbank.nus.edu.sg/handle/10635/219438 | ISSN: | 1043-2760 1879-3061 |
DOI: | 10.1016/j.tem.2021.11.003 |
| Appears in Collections: | Staff Publications Elements |
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| File | Description | Size | Format | Access Settings | Version | |
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| Gyanwali B.. Goh J. Trends Endocrinol Metab 2022 - Alpha-Ketoglutarate dietary supplementation to improve health in humans.pdf | 1.41 MB | Adobe PDF | CLOSED | None |
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