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Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.tem.2021.11.003
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dc.titleAlpha-Ketoglutarate dietary supplementation to improve health in humans
dc.contributor.authorGyanwali, Bibek
dc.contributor.authorLim, Zi Xiang
dc.contributor.authorSoh, Janjira
dc.contributor.authorLim, Clarissa
dc.contributor.authorGuan, Shou Ping
dc.contributor.authorGoh, Jorming
dc.contributor.authorMaier, Andrea B
dc.contributor.authorKennedy, Brian K
dc.date.accessioned2022-04-21T04:45:16Z
dc.date.available2022-04-21T04:45:16Z
dc.date.issued2022-02-01
dc.identifier.citationGyanwali, Bibek, Lim, Zi Xiang, Soh, Janjira, Lim, Clarissa, Guan, Shou Ping, Goh, Jorming, Maier, Andrea B, Kennedy, Brian K (2022-02-01). Alpha-Ketoglutarate dietary supplementation to improve health in humans. TRENDS IN ENDOCRINOLOGY AND METABOLISM 33 (2) : 136-146. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tem.2021.11.003
dc.identifier.issn1043-2760
dc.identifier.issn1879-3061
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/219438
dc.description.abstractAlpha-ketoglutarate (AKG) is an intermediate in the Krebs cycle involved in various metabolic and cellular pathways. As an antioxidant, AKG interferes in nitrogen and ammonia balance, and affects epigenetic and immune regulation. These pleiotropic functions of AKG suggest it may also extend human healthspan. Recent studies in worms and mice support this concept. A few studies published in the 1980s and 1990s in humans suggested the potential benefits of AKG in muscle growth, wound healing, and in promoting faster recovery after surgery. So far there are no recently published studies demonstrating the role of AKG in treating aging and age-related diseases; hence, further clinical studies are required to better understand the role of AKG in humans. This review will discuss the regulatory role of AKG in aging, as well as its potential therapeutic use in humans to treat age-related diseases.
dc.language.isoen
dc.publisherELSEVIER SCIENCE LONDON
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectEndocrinology & Metabolism
dc.subjectDOUBLE-BLIND TRIAL
dc.subjectOXIDATIVE STRESS
dc.subjectCALORIC RESTRICTION
dc.subjectPROTEIN-SYNTHESIS
dc.subjectBRAIN METABOLISM
dc.subjectSODIUM-SALT
dc.subjectAMINO-ACID
dc.subjectLIFE-SPAN
dc.subjectPLASMA
dc.subjectHYPOXIA
dc.typeReview
dc.date.updated2022-04-21T01:36:05Z
dc.contributor.departmentBIOCHEMISTRY
dc.contributor.departmentMEDICINE
dc.contributor.departmentPHYSIOLOGY
dc.description.doi10.1016/j.tem.2021.11.003
dc.description.sourcetitleTRENDS IN ENDOCRINOLOGY AND METABOLISM
dc.description.volume33
dc.description.issue2
dc.description.page136-146
dc.published.statePublished
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