Please use this identifier to cite or link to this item: https://doi.org/10.3390/ijerph181910205
Title: Mindfulness Awareness Practice (MAP) to Prevent Dementia in Older Adults with Mild Cognitive Impairment: Protocol of a Randomized Controlled Trial and Implementation Outcomes
Authors: Ng, Ted Kheng Siang
Feng, Lei 
Fam, Johnson 
Rawtaer, Iris 
Kumar, Alan Prem 
Rane, Grishma 
Cheah, Irwin Kee-Mun 
Mahendran, Ratha 
Lee, Yuan Kun 
Tan, Ene Choo 
Goh, Lee Gan 
Kua, Ee Heok 
Mahendran, Rathi 
Keywords: Science & Technology
Life Sciences & Biomedicine
Environmental Sciences
Public, Environmental & Occupational Health
Environmental Sciences & Ecology
mild cognitive impairment
aging
psychiatry
preclinical dementia
non-pharmacological intervention
mindfulness
health education
biomarker
neuroimaging
ALZHEIMERS-DISEASE
INTERVENTION
MEDITATION
ATTENTION
STRESS
PREVALENCE
THERAPY
PROGRAM
PEOPLE
RISK
Issue Date: 1-Oct-2021
Publisher: MDPI
Citation: Ng, Ted Kheng Siang, Feng, Lei, Fam, Johnson, Rawtaer, Iris, Kumar, Alan Prem, Rane, Grishma, Cheah, Irwin Kee-Mun, Mahendran, Ratha, Lee, Yuan Kun, Tan, Ene Choo, Goh, Lee Gan, Kua, Ee Heok, Mahendran, Rathi (2021-10-01). Mindfulness Awareness Practice (MAP) to Prevent Dementia in Older Adults with Mild Cognitive Impairment: Protocol of a Randomized Controlled Trial and Implementation Outcomes. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 18 (19). ScholarBank@NUS Repository. https://doi.org/10.3390/ijerph181910205
Abstract: Background: With an aging population, developing non-pharmacological interventions (NPIs) to delay dementia has become critical. Apart from cognitive decline, dementia is associated with multiple pathophysiology, including increased oxidative stress, dysregulated gene expressions, cytokine, neurotrophin, and stress markers, telomere shortening, and deteriorations in brain connec-tivity. Although mindfulness practices have been proposed to ameliorate these biological changes, no empirical studies were conducted. We thus aimed to investigate the effects of mindfulness awareness practice (MAP) to prevent cognitive decline and improve peripheral biomarkers in community-dwelling older adults diagnosed with mild cognitive impairment (MCI). Methods/Design: This was a single-blinded and parallel-group randomized controlled trial with two arms (intervention and active control arms), conducted over nine months. A total of 60 consenting community-dwelling older adults diagnosed with MCI were planned to be randomized in a 1:1 ratio to either the MAP or the Health Education Program (HEP). Interventions were performed weekly for the initial 12 weeks, and monthly for the subsequent six months. Outcome measures were assessed at baseline, 3-month, and 9-month post-intervention by blinded assessors. Primary outcomes were neurocognitive tests, comprehensive peripheral biomarkers, and brain imaging scans. Secondary outcomes included basic health screening measures, affective symptoms, and measures of physical functions. Linear-mixed models were used to examine the effects of MAP on these outcome measures. Significance: This is the first randomized controlled trial to systematically investigate the effects of a mindfulness intervention in improving cognitive functions and various biomarkers in community-dwelling older adults diagnosed with MCI. Our findings have the potential to inform mindfulness intervention as a novel approach to delay dementia.
Source Title: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
URI: https://scholarbank.nus.edu.sg/handle/10635/218881
ISSN: 16617827
16604601
DOI: 10.3390/ijerph181910205
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