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https://doi.org/10.1186/s13024-021-00506-8
Title: | The role of inflammasomes in vascular cognitive impairment | Authors: | Poh, Luting Sim, Wei Liang Jo, Dong-Gyu Dinh, Quynh Nhu Drummond, Grant R Sobey, Christopher G Chen, Christopher Li-Hsian Lai, Mitchell KP Fann, David Y Arumugam, Thiruma V |
Keywords: | Science & Technology Life Sciences & Biomedicine Neurosciences Neurosciences & Neurology Inflammasome Inflammation Chronic cerebral Hypoperfusion Vascular cognitive impairment Vascular dementia BLOOD-BRAIN-BARRIER CHRONIC CEREBRAL HYPOPERFUSION WHITE-MATTER LESIONS NF-KAPPA-B SMALL VESSEL DISEASE ALZHEIMERS-DISEASE NLRP3 INFLAMMASOME OXIDATIVE STRESS AIM2 INFLAMMASOME NEURONAL DEATH |
Issue Date: | 9-Jan-2022 | Publisher: | BMC | Citation: | Poh, Luting, Sim, Wei Liang, Jo, Dong-Gyu, Dinh, Quynh Nhu, Drummond, Grant R, Sobey, Christopher G, Chen, Christopher Li-Hsian, Lai, Mitchell KP, Fann, David Y, Arumugam, Thiruma V (2022-01-09). The role of inflammasomes in vascular cognitive impairment. MOLECULAR NEURODEGENERATION 17 (1). ScholarBank@NUS Repository. https://doi.org/10.1186/s13024-021-00506-8 | Abstract: | There is an increasing prevalence of Vascular Cognitive Impairment (VCI) worldwide, and several studies have suggested that Chronic Cerebral Hypoperfusion (CCH) plays a critical role in disease onset and progression. However, there is a limited understanding of the underlying pathophysiology of VCI, especially in relation to CCH. Neuroinflammation is a significant contributor in the progression of VCI as increased systemic levels of the proinflammatory cytokine interleukin-1β (IL-1β) has been extensively reported in VCI patients. Recently it has been established that CCH can activate the inflammasome signaling pathways, involving NLRP3 and AIM2 inflammasomes that critically regulate IL-1β production. Given that neuroinflammation is an early event in VCI, it is important that we understand its molecular and cellular mechanisms to enable development of disease-modifying treatments to reduce the structural brain damage and cognitive deficits that are observed clinically in the elderly. Hence, this review aims to provide a comprehensive insight into the molecular and cellular mechanisms involved in the pathogenesis of CCH-induced inflammasome signaling in VCI. | Source Title: | MOLECULAR NEURODEGENERATION | URI: | https://scholarbank.nus.edu.sg/handle/10635/218716 | ISSN: | 1750-1326 | DOI: | 10.1186/s13024-021-00506-8 |
Appears in Collections: | Staff Publications Elements |
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