Please use this identifier to cite or link to this item:
https://doi.org/10.1186/s13024-021-00506-8
DC Field | Value | |
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dc.title | The role of inflammasomes in vascular cognitive impairment | |
dc.contributor.author | Poh, Luting | |
dc.contributor.author | Sim, Wei Liang | |
dc.contributor.author | Jo, Dong-Gyu | |
dc.contributor.author | Dinh, Quynh Nhu | |
dc.contributor.author | Drummond, Grant R | |
dc.contributor.author | Sobey, Christopher G | |
dc.contributor.author | Chen, Christopher Li-Hsian | |
dc.contributor.author | Lai, Mitchell KP | |
dc.contributor.author | Fann, David Y | |
dc.contributor.author | Arumugam, Thiruma V | |
dc.date.accessioned | 2022-04-08T06:05:19Z | |
dc.date.available | 2022-04-08T06:05:19Z | |
dc.date.issued | 2022-01-09 | |
dc.identifier.citation | Poh, Luting, Sim, Wei Liang, Jo, Dong-Gyu, Dinh, Quynh Nhu, Drummond, Grant R, Sobey, Christopher G, Chen, Christopher Li-Hsian, Lai, Mitchell KP, Fann, David Y, Arumugam, Thiruma V (2022-01-09). The role of inflammasomes in vascular cognitive impairment. MOLECULAR NEURODEGENERATION 17 (1). ScholarBank@NUS Repository. https://doi.org/10.1186/s13024-021-00506-8 | |
dc.identifier.issn | 1750-1326 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/218716 | |
dc.description.abstract | There is an increasing prevalence of Vascular Cognitive Impairment (VCI) worldwide, and several studies have suggested that Chronic Cerebral Hypoperfusion (CCH) plays a critical role in disease onset and progression. However, there is a limited understanding of the underlying pathophysiology of VCI, especially in relation to CCH. Neuroinflammation is a significant contributor in the progression of VCI as increased systemic levels of the proinflammatory cytokine interleukin-1β (IL-1β) has been extensively reported in VCI patients. Recently it has been established that CCH can activate the inflammasome signaling pathways, involving NLRP3 and AIM2 inflammasomes that critically regulate IL-1β production. Given that neuroinflammation is an early event in VCI, it is important that we understand its molecular and cellular mechanisms to enable development of disease-modifying treatments to reduce the structural brain damage and cognitive deficits that are observed clinically in the elderly. Hence, this review aims to provide a comprehensive insight into the molecular and cellular mechanisms involved in the pathogenesis of CCH-induced inflammasome signaling in VCI. | |
dc.language.iso | en | |
dc.publisher | BMC | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Neurosciences | |
dc.subject | Neurosciences & Neurology | |
dc.subject | Inflammasome | |
dc.subject | Inflammation | |
dc.subject | Chronic cerebral Hypoperfusion | |
dc.subject | Vascular cognitive impairment | |
dc.subject | Vascular dementia | |
dc.subject | BLOOD-BRAIN-BARRIER | |
dc.subject | CHRONIC CEREBRAL HYPOPERFUSION | |
dc.subject | WHITE-MATTER LESIONS | |
dc.subject | NF-KAPPA-B | |
dc.subject | SMALL VESSEL DISEASE | |
dc.subject | ALZHEIMERS-DISEASE | |
dc.subject | NLRP3 INFLAMMASOME | |
dc.subject | OXIDATIVE STRESS | |
dc.subject | AIM2 INFLAMMASOME | |
dc.subject | NEURONAL DEATH | |
dc.type | Review | |
dc.date.updated | 2022-04-08T02:17:42Z | |
dc.contributor.department | PHYSIOLOGY | |
dc.contributor.department | PHARMACOLOGY | |
dc.description.doi | 10.1186/s13024-021-00506-8 | |
dc.description.sourcetitle | MOLECULAR NEURODEGENERATION | |
dc.description.volume | 17 | |
dc.description.issue | 1 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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The role of inflammasomes in vascular cognitive impairment.pdf | 2.07 MB | Adobe PDF | OPEN | None | View/Download |
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