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https://doi.org/10.1038/ncomms11702
Title: | Tumour-initiating cell-specific miR-1246 and miR-1290 expression converge to promote non-small cell lung cancer progression | Authors: | Zhang, Wen Cai Chin, Tan Min Yang, Henry Nga, Min En Lunny, Declan Patrick Lim, Edwin Kok Hao Sun, Li Li Pang, Yin Huei Leow, Yi Ning Malusay, Shanneen Rossellini Y Lim, Priscilla Xin Hui Lee, Jeravan Zili Tan, Benedict Jian Wei Ng, Shyh-Chang Lim, Elaine Hsuen Lim, Wan Teck Tan, Daniel Shao Weng Tan, Eng Huat Tai, Bee Choo Soo, Ross Andrew Tam, Wai Leong Lim, Bing |
Keywords: | Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics STEM-CELLS SELF-RENEWAL METALLOTHIONEIN 1G MIR-17-92 CLUSTER MICRORNAS GROWTH FAMILY LET-7 PROLIFERATION SUPPRESSOR |
Issue Date: | 1-Jun-2016 | Publisher: | NATURE PUBLISHING GROUP | Citation: | Zhang, Wen Cai, Chin, Tan Min, Yang, Henry, Nga, Min En, Lunny, Declan Patrick, Lim, Edwin Kok Hao, Sun, Li Li, Pang, Yin Huei, Leow, Yi Ning, Malusay, Shanneen Rossellini Y, Lim, Priscilla Xin Hui, Lee, Jeravan Zili, Tan, Benedict Jian Wei, Ng, Shyh-Chang, Lim, Elaine Hsuen, Lim, Wan Teck, Tan, Daniel Shao Weng, Tan, Eng Huat, Tai, Bee Choo, Soo, Ross Andrew, Tam, Wai Leong, Lim, Bing (2016-06-01). Tumour-initiating cell-specific miR-1246 and miR-1290 expression converge to promote non-small cell lung cancer progression. NATURE COMMUNICATIONS 7 (1). ScholarBank@NUS Repository. https://doi.org/10.1038/ncomms11702 | Abstract: | The tumour-initiating cell (TIC) model accounts for phenotypic and functional heterogeneity among tumour cells. MicroRNAs (miRNAs) are regulatory molecules frequently aberrantly expressed in cancers, and may contribute towards tumour heterogeneity and TIC behaviour. More recent efforts have focused on miRNAs as diagnostic or therapeutic targets. Here, we identified the TIC-specific miRNAs, miR-1246 and miR-1290, as crucial drivers for tumour initiation and cancer progression in human non-small cell lung cancer. The loss of either miRNA impacted the tumour-initiating potential of TICs and their ability to metastasize. Longitudinal analyses of serum miR-1246 and miR-1290 levels across time correlate their circulating levels to the clinical response of lung cancer patients who were receiving ongoing anti-neoplastic therapies. Functionally, direct inhibition of either miRNA with locked nucleic acid administered systemically, can arrest the growth of established patient-derived xenograft tumours, thus indicating that these miRNAs are clinically useful as biomarkers for tracking disease progression and as therapeutic targets. | Source Title: | NATURE COMMUNICATIONS | URI: | https://scholarbank.nus.edu.sg/handle/10635/218618 | ISSN: | 20411723 | DOI: | 10.1038/ncomms11702 |
Appears in Collections: | Staff Publications Elements |
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