Please use this identifier to cite or link to this item: https://doi.org/10.1038/ncomms11702
Title: Tumour-initiating cell-specific miR-1246 and miR-1290 expression converge to promote non-small cell lung cancer progression
Authors: Zhang, Wen Cai
Chin, Tan Min 
Yang, Henry
Nga, Min En 
Lunny, Declan Patrick
Lim, Edwin Kok Hao
Sun, Li Li
Pang, Yin Huei 
Leow, Yi Ning
Malusay, Shanneen Rossellini Y
Lim, Priscilla Xin Hui
Lee, Jeravan Zili
Tan, Benedict Jian Wei
Ng, Shyh-Chang 
Lim, Elaine Hsuen 
Lim, Wan Teck 
Tan, Daniel Shao Weng 
Tan, Eng Huat 
Tai, Bee Choo 
Soo, Ross Andrew 
Tam, Wai Leong 
Lim, Bing
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
STEM-CELLS
SELF-RENEWAL
METALLOTHIONEIN 1G
MIR-17-92 CLUSTER
MICRORNAS
GROWTH
FAMILY
LET-7
PROLIFERATION
SUPPRESSOR
Issue Date: 1-Jun-2016
Publisher: NATURE PUBLISHING GROUP
Citation: Zhang, Wen Cai, Chin, Tan Min, Yang, Henry, Nga, Min En, Lunny, Declan Patrick, Lim, Edwin Kok Hao, Sun, Li Li, Pang, Yin Huei, Leow, Yi Ning, Malusay, Shanneen Rossellini Y, Lim, Priscilla Xin Hui, Lee, Jeravan Zili, Tan, Benedict Jian Wei, Ng, Shyh-Chang, Lim, Elaine Hsuen, Lim, Wan Teck, Tan, Daniel Shao Weng, Tan, Eng Huat, Tai, Bee Choo, Soo, Ross Andrew, Tam, Wai Leong, Lim, Bing (2016-06-01). Tumour-initiating cell-specific miR-1246 and miR-1290 expression converge to promote non-small cell lung cancer progression. NATURE COMMUNICATIONS 7 (1). ScholarBank@NUS Repository. https://doi.org/10.1038/ncomms11702
Abstract: The tumour-initiating cell (TIC) model accounts for phenotypic and functional heterogeneity among tumour cells. MicroRNAs (miRNAs) are regulatory molecules frequently aberrantly expressed in cancers, and may contribute towards tumour heterogeneity and TIC behaviour. More recent efforts have focused on miRNAs as diagnostic or therapeutic targets. Here, we identified the TIC-specific miRNAs, miR-1246 and miR-1290, as crucial drivers for tumour initiation and cancer progression in human non-small cell lung cancer. The loss of either miRNA impacted the tumour-initiating potential of TICs and their ability to metastasize. Longitudinal analyses of serum miR-1246 and miR-1290 levels across time correlate their circulating levels to the clinical response of lung cancer patients who were receiving ongoing anti-neoplastic therapies. Functionally, direct inhibition of either miRNA with locked nucleic acid administered systemically, can arrest the growth of established patient-derived xenograft tumours, thus indicating that these miRNAs are clinically useful as biomarkers for tracking disease progression and as therapeutic targets.
Source Title: NATURE COMMUNICATIONS
URI: https://scholarbank.nus.edu.sg/handle/10635/218618
ISSN: 20411723
DOI: 10.1038/ncomms11702
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