Please use this identifier to cite or link to this item: https://doi.org/10.1038/ncomms11702
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dc.titleTumour-initiating cell-specific miR-1246 and miR-1290 expression converge to promote non-small cell lung cancer progression
dc.contributor.authorZhang, Wen Cai
dc.contributor.authorChin, Tan Min
dc.contributor.authorYang, Henry
dc.contributor.authorNga, Min En
dc.contributor.authorLunny, Declan Patrick
dc.contributor.authorLim, Edwin Kok Hao
dc.contributor.authorSun, Li Li
dc.contributor.authorPang, Yin Huei
dc.contributor.authorLeow, Yi Ning
dc.contributor.authorMalusay, Shanneen Rossellini Y
dc.contributor.authorLim, Priscilla Xin Hui
dc.contributor.authorLee, Jeravan Zili
dc.contributor.authorTan, Benedict Jian Wei
dc.contributor.authorNg, Shyh-Chang
dc.contributor.authorLim, Elaine Hsuen
dc.contributor.authorLim, Wan Teck
dc.contributor.authorTan, Daniel Shao Weng
dc.contributor.authorTan, Eng Huat
dc.contributor.authorTai, Bee Choo
dc.contributor.authorSoo, Ross Andrew
dc.contributor.authorTam, Wai Leong
dc.contributor.authorLim, Bing
dc.date.accessioned2022-04-07T08:55:55Z
dc.date.available2022-04-07T08:55:55Z
dc.date.issued2016-06-01
dc.identifier.citationZhang, Wen Cai, Chin, Tan Min, Yang, Henry, Nga, Min En, Lunny, Declan Patrick, Lim, Edwin Kok Hao, Sun, Li Li, Pang, Yin Huei, Leow, Yi Ning, Malusay, Shanneen Rossellini Y, Lim, Priscilla Xin Hui, Lee, Jeravan Zili, Tan, Benedict Jian Wei, Ng, Shyh-Chang, Lim, Elaine Hsuen, Lim, Wan Teck, Tan, Daniel Shao Weng, Tan, Eng Huat, Tai, Bee Choo, Soo, Ross Andrew, Tam, Wai Leong, Lim, Bing (2016-06-01). Tumour-initiating cell-specific miR-1246 and miR-1290 expression converge to promote non-small cell lung cancer progression. NATURE COMMUNICATIONS 7 (1). ScholarBank@NUS Repository. https://doi.org/10.1038/ncomms11702
dc.identifier.issn20411723
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/218618
dc.description.abstractThe tumour-initiating cell (TIC) model accounts for phenotypic and functional heterogeneity among tumour cells. MicroRNAs (miRNAs) are regulatory molecules frequently aberrantly expressed in cancers, and may contribute towards tumour heterogeneity and TIC behaviour. More recent efforts have focused on miRNAs as diagnostic or therapeutic targets. Here, we identified the TIC-specific miRNAs, miR-1246 and miR-1290, as crucial drivers for tumour initiation and cancer progression in human non-small cell lung cancer. The loss of either miRNA impacted the tumour-initiating potential of TICs and their ability to metastasize. Longitudinal analyses of serum miR-1246 and miR-1290 levels across time correlate their circulating levels to the clinical response of lung cancer patients who were receiving ongoing anti-neoplastic therapies. Functionally, direct inhibition of either miRNA with locked nucleic acid administered systemically, can arrest the growth of established patient-derived xenograft tumours, thus indicating that these miRNAs are clinically useful as biomarkers for tracking disease progression and as therapeutic targets.
dc.language.isoen
dc.publisherNATURE PUBLISHING GROUP
dc.sourceElements
dc.subjectScience & Technology
dc.subjectMultidisciplinary Sciences
dc.subjectScience & Technology - Other Topics
dc.subjectSTEM-CELLS
dc.subjectSELF-RENEWAL
dc.subjectMETALLOTHIONEIN 1G
dc.subjectMIR-17-92 CLUSTER
dc.subjectMICRORNAS
dc.subjectGROWTH
dc.subjectFAMILY
dc.subjectLET-7
dc.subjectPROLIFERATION
dc.subjectSUPPRESSOR
dc.typeArticle
dc.date.updated2022-04-07T02:41:00Z
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.contributor.departmentDEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
dc.contributor.departmentBIOCHEMISTRY
dc.contributor.departmentORTHOPAEDIC SURGERY
dc.contributor.departmentPATHOLOGY
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.contributor.departmentMEDICINE
dc.description.doi10.1038/ncomms11702
dc.description.sourcetitleNATURE COMMUNICATIONS
dc.description.volume7
dc.description.issue1
dc.published.statePublished
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