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https://doi.org/10.1016/j.jacbts.2017.12.005
| Title: | Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction | Authors: | de Carvalho, Leonardo P Tan, Sock Hwee Ow, Ghim-Siong Tang, Zhiqun Ching, Jianhong Kovalik, Jean-Paul Poh, Sock Cheng Chin, Chee-Tang Richards, A Mark Martinez, Eliana C Troughton, Richard W Fong, Alan Yean-Yip Yan, Bryan P Seneviratna, Aruni Sorokin, Vitaly Summers, Scott A Kuznetsov, Vladimir A Chan, Mark Y |
Keywords: | Science & Technology Life Sciences & Biomedicine Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology |
Issue Date: | 1-Apr-2018 | Publisher: | ELSEVIER SCIENCE INC | Citation: | de Carvalho, Leonardo P, Tan, Sock Hwee, Ow, Ghim-Siong, Tang, Zhiqun, Ching, Jianhong, Kovalik, Jean-Paul, Poh, Sock Cheng, Chin, Chee-Tang, Richards, A Mark, Martinez, Eliana C, Troughton, Richard W, Fong, Alan Yean-Yip, Yan, Bryan P, Seneviratna, Aruni, Sorokin, Vitaly, Summers, Scott A, Kuznetsov, Vladimir A, Chan, Mark Y (2018-04-01). Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction. JACC-BASIC TO TRANSLATIONAL SCIENCE 3 (2) : 163-163. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jacbts.2017.12.005 | Abstract: | We identified a plasma signature of 11 C14 to C26 ceramides and 1 C16 dihydroceramide predictive of major adverse cardiovascular events in patients with acute myocardial infarction (AMI). Among patients undergoing coronary artery bypass surgery, those with recent AMI, compared with those without recent AMI, showed a significant increase in 5 of the signature's 12 ceramides in plasma but not simultaneously-biopsied aortic tissue. In contrast, a rat AMI model, compared with sham control, showed a significant increase in myocardial concentrations of all 12 ceramides and up-regulation of 3 ceramide-producing enzymes, suggesting ischemic myocardium as a possible source of this ceramide signature. | Source Title: | JACC-BASIC TO TRANSLATIONAL SCIENCE | URI: | https://scholarbank.nus.edu.sg/handle/10635/206149 | ISSN: | 2452302X | DOI: | 10.1016/j.jacbts.2017.12.005 |
| Appears in Collections: | Elements Staff Publications |
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