Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jacbts.2017.12.005
Title: Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction
Authors: de Carvalho, Leonardo P 
Tan, Sock Hwee 
Ow, Ghim-Siong
Tang, Zhiqun
Ching, Jianhong 
Kovalik, Jean-Paul
Poh, Sock Cheng
Chin, Chee-Tang 
Richards, A Mark 
Martinez, Eliana C 
Troughton, Richard W
Fong, Alan Yean-Yip
Yan, Bryan P
Seneviratna, Aruni
Sorokin, Vitaly
Summers, Scott A
Kuznetsov, Vladimir A
Chan, Mark Y 
Keywords: Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Cardiovascular System & Cardiology
Issue Date: 1-Apr-2018
Publisher: ELSEVIER SCIENCE INC
Citation: de Carvalho, Leonardo P, Tan, Sock Hwee, Ow, Ghim-Siong, Tang, Zhiqun, Ching, Jianhong, Kovalik, Jean-Paul, Poh, Sock Cheng, Chin, Chee-Tang, Richards, A Mark, Martinez, Eliana C, Troughton, Richard W, Fong, Alan Yean-Yip, Yan, Bryan P, Seneviratna, Aruni, Sorokin, Vitaly, Summers, Scott A, Kuznetsov, Vladimir A, Chan, Mark Y (2018-04-01). Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction. JACC-BASIC TO TRANSLATIONAL SCIENCE 3 (2) : 163-163. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jacbts.2017.12.005
Abstract: We identified a plasma signature of 11 C14 to C26 ceramides and 1 C16 dihydroceramide predictive of major adverse cardiovascular events in patients with acute myocardial infarction (AMI). Among patients undergoing coronary artery bypass surgery, those with recent AMI, compared with those without recent AMI, showed a significant increase in 5 of the signature's 12 ceramides in plasma but not simultaneously-biopsied aortic tissue. In contrast, a rat AMI model, compared with sham control, showed a significant increase in myocardial concentrations of all 12 ceramides and up-regulation of 3 ceramide-producing enzymes, suggesting ischemic myocardium as a possible source of this ceramide signature.
Source Title: JACC-BASIC TO TRANSLATIONAL SCIENCE
URI: https://scholarbank.nus.edu.sg/handle/10635/206149
ISSN: 2452302X
DOI: 10.1016/j.jacbts.2017.12.005
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