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Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jacbts.2017.12.005
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dc.titlePlasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction
dc.contributor.authorde Carvalho, Leonardo P
dc.contributor.authorTan, Sock Hwee
dc.contributor.authorOw, Ghim-Siong
dc.contributor.authorTang, Zhiqun
dc.contributor.authorChing, Jianhong
dc.contributor.authorKovalik, Jean-Paul
dc.contributor.authorPoh, Sock Cheng
dc.contributor.authorChin, Chee-Tang
dc.contributor.authorRichards, A Mark
dc.contributor.authorMartinez, Eliana C
dc.contributor.authorTroughton, Richard W
dc.contributor.authorFong, Alan Yean-Yip
dc.contributor.authorYan, Bryan P
dc.contributor.authorSeneviratna, Aruni
dc.contributor.authorSorokin, Vitaly
dc.contributor.authorSummers, Scott A
dc.contributor.authorKuznetsov, Vladimir A
dc.contributor.authorChan, Mark Y
dc.date.accessioned2021-11-15T05:51:04Z
dc.date.available2021-11-15T05:51:04Z
dc.date.issued2018-04-01
dc.identifier.citationde Carvalho, Leonardo P, Tan, Sock Hwee, Ow, Ghim-Siong, Tang, Zhiqun, Ching, Jianhong, Kovalik, Jean-Paul, Poh, Sock Cheng, Chin, Chee-Tang, Richards, A Mark, Martinez, Eliana C, Troughton, Richard W, Fong, Alan Yean-Yip, Yan, Bryan P, Seneviratna, Aruni, Sorokin, Vitaly, Summers, Scott A, Kuznetsov, Vladimir A, Chan, Mark Y (2018-04-01). Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction. JACC-BASIC TO TRANSLATIONAL SCIENCE 3 (2) : 163-163. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jacbts.2017.12.005
dc.identifier.issn2452302X
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/206149
dc.description.abstractWe identified a plasma signature of 11 C14 to C26 ceramides and 1 C16 dihydroceramide predictive of major adverse cardiovascular events in patients with acute myocardial infarction (AMI). Among patients undergoing coronary artery bypass surgery, those with recent AMI, compared with those without recent AMI, showed a significant increase in 5 of the signature's 12 ceramides in plasma but not simultaneously-biopsied aortic tissue. In contrast, a rat AMI model, compared with sham control, showed a significant increase in myocardial concentrations of all 12 ceramides and up-regulation of 3 ceramide-producing enzymes, suggesting ischemic myocardium as a possible source of this ceramide signature.
dc.language.isoen
dc.publisherELSEVIER SCIENCE INC
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectCardiac & Cardiovascular Systems
dc.subjectCardiovascular System & Cardiology
dc.typeEditorial
dc.date.updated2021-11-11T03:02:45Z
dc.contributor.departmentMEDICINE
dc.contributor.departmentDEPT OF SURGERY
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1016/j.jacbts.2017.12.005
dc.description.sourcetitleJACC-BASIC TO TRANSLATIONAL SCIENCE
dc.description.volume3
dc.description.issue2
dc.description.page163-163
dc.published.statePublished
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