Please use this identifier to cite or link to this item: https://doi.org/10.1021/acsnano.0c04518
Title: Tumor-Activated and Metal-Organic Framework Assisted Self-Assembly of Organic Photosensitizers
Authors: Wang, Yuanbo 
Shi, Leilei 
Ma, Dou
Xu, Shidang 
Wu, Wenbo 
Xu, Li
Panahandeh-Fard, Majid 
Zhu, Xinyuan
Wang, Bo
Liu, Bin 
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Chemistry, Physical
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Chemistry
Science & Technology - Other Topics
Materials Science
photosensitizers
aggregation-induced emission
self-assembly
metal-organic framework
photodynamtc therapy
AGGREGATION-INDUCED EMISSION
PHOTODYNAMIC THERAPY
DELAYED FLUORESCENCE
REACTIVE OXYGEN
CHARGE-TRANSFER
NANOPARTICLES
GLUTATHIONE
DELIVERY
CELL
CONSTRUCTION
Issue Date: 2020
Publisher: AMER CHEMICAL SOC
Citation: Wang, Yuanbo, Shi, Leilei, Ma, Dou, Xu, Shidang, Wu, Wenbo, Xu, Li, Panahandeh-Fard, Majid, Zhu, Xinyuan, Wang, Bo, Liu, Bin (2020). Tumor-Activated and Metal-Organic Framework Assisted Self-Assembly of Organic Photosensitizers. ACS NANO 14 (10) : 13056-13068. ScholarBank@NUS Repository. https://doi.org/10.1021/acsnano.0c04518
Abstract: © 2020 American Chemical Society Tumor accumulation and intratumoral singlet oxygen (1O2) generation efficiency of photosensitizers (PSs) are two essential factors that determine their photodynamic therapy (PDT) efficacies. How to maximize the PS performance at the tumor site is of great research interest. Herein, we report a metal-organic framework (ZIF-8, ZIF = zeolitic imidazolate framework) assisted in vivo self-assembly nanoplatform, ZIF-8-PMMA-S-S-mPEG, as an effective tool for organic PS payloads to achieve efficient PDT. Using an organic PS with aggregation-induced emission as an example, under intratumoral bioreduction, PS-loaded ZIF-8-PMMA-S-S-mPEG (PS@ZIF-8-PMMA-S-S-mPEG) was self-assembled into large ordered hydrophobic clusters, which greatly enhance tumor retention and accumulation of the PS. Moreover, hydrophobic ZIF-8 assemblies greatly isolate the loaded PSs from water and improve O2 transport for the PSs to effectively produce 1O2 inside tumors under light irradiation. The organic PS is therefore endowed with optimal tumor accumulation and intratumoral 1O2 production, demonstrating the effectiveness of the developed self-assembly strategy in PDT application.
Source Title: ACS NANO
URI: https://scholarbank.nus.edu.sg/handle/10635/188643
ISSN: 19360851
1936086X
DOI: 10.1021/acsnano.0c04518
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