Please use this identifier to cite or link to this item: https://doi.org/10.1021/acsnano.0c04518
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dc.titleTumor-Activated and Metal-Organic Framework Assisted Self-Assembly of Organic Photosensitizers
dc.contributor.authorWang, Yuanbo
dc.contributor.authorShi, Leilei
dc.contributor.authorMa, Dou
dc.contributor.authorXu, Shidang
dc.contributor.authorWu, Wenbo
dc.contributor.authorXu, Li
dc.contributor.authorPanahandeh-Fard, Majid
dc.contributor.authorZhu, Xinyuan
dc.contributor.authorWang, Bo
dc.contributor.authorLiu, Bin
dc.date.accessioned2021-04-07T06:31:34Z
dc.date.available2021-04-07T06:31:34Z
dc.date.issued2020
dc.identifier.citationWang, Yuanbo, Shi, Leilei, Ma, Dou, Xu, Shidang, Wu, Wenbo, Xu, Li, Panahandeh-Fard, Majid, Zhu, Xinyuan, Wang, Bo, Liu, Bin (2020). Tumor-Activated and Metal-Organic Framework Assisted Self-Assembly of Organic Photosensitizers. ACS NANO 14 (10) : 13056-13068. ScholarBank@NUS Repository. https://doi.org/10.1021/acsnano.0c04518
dc.identifier.issn19360851
dc.identifier.issn1936086X
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/188643
dc.description.abstract© 2020 American Chemical Society Tumor accumulation and intratumoral singlet oxygen (1O2) generation efficiency of photosensitizers (PSs) are two essential factors that determine their photodynamic therapy (PDT) efficacies. How to maximize the PS performance at the tumor site is of great research interest. Herein, we report a metal-organic framework (ZIF-8, ZIF = zeolitic imidazolate framework) assisted in vivo self-assembly nanoplatform, ZIF-8-PMMA-S-S-mPEG, as an effective tool for organic PS payloads to achieve efficient PDT. Using an organic PS with aggregation-induced emission as an example, under intratumoral bioreduction, PS-loaded ZIF-8-PMMA-S-S-mPEG (PS@ZIF-8-PMMA-S-S-mPEG) was self-assembled into large ordered hydrophobic clusters, which greatly enhance tumor retention and accumulation of the PS. Moreover, hydrophobic ZIF-8 assemblies greatly isolate the loaded PSs from water and improve O2 transport for the PSs to effectively produce 1O2 inside tumors under light irradiation. The organic PS is therefore endowed with optimal tumor accumulation and intratumoral 1O2 production, demonstrating the effectiveness of the developed self-assembly strategy in PDT application.
dc.language.isoen
dc.publisherAMER CHEMICAL SOC
dc.sourceElements
dc.subjectScience & Technology
dc.subjectPhysical Sciences
dc.subjectTechnology
dc.subjectChemistry, Multidisciplinary
dc.subjectChemistry, Physical
dc.subjectNanoscience & Nanotechnology
dc.subjectMaterials Science, Multidisciplinary
dc.subjectChemistry
dc.subjectScience & Technology - Other Topics
dc.subjectMaterials Science
dc.subjectphotosensitizers
dc.subjectaggregation-induced emission
dc.subjectself-assembly
dc.subjectmetal-organic framework
dc.subjectphotodynamtc therapy
dc.subjectAGGREGATION-INDUCED EMISSION
dc.subjectPHOTODYNAMIC THERAPY
dc.subjectDELAYED FLUORESCENCE
dc.subjectREACTIVE OXYGEN
dc.subjectCHARGE-TRANSFER
dc.subjectNANOPARTICLES
dc.subjectGLUTATHIONE
dc.subjectDELIVERY
dc.subjectCELL
dc.subjectCONSTRUCTION
dc.typeArticle
dc.date.updated2021-04-07T01:25:48Z
dc.contributor.departmentDEPT OF CHEMICAL & BIOMOLECULAR ENGG
dc.contributor.departmentDEPT OF MATERIALS SCIENCE & ENGINEERING
dc.contributor.departmentNUS NANOSCIENCE & NANOTECH INITIATIVE
dc.description.doi10.1021/acsnano.0c04518
dc.description.sourcetitleACS NANO
dc.description.volume14
dc.description.issue10
dc.description.page13056-13068
dc.published.statePublished
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