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https://doi.org/10.1016/j.nbd.2005.12.016
| Title: | Selective effects of the APOE epsilon 4 allele on presynaptic cholinergic markers in the neocortex of Alzheimer's disease | Authors: | Lai, Mitchell KP Tsang, Shirley WY Garcia-Alloza, Monica Minger, Stephen L Nicoll, James AR Esiri, Margaret M Wong, Peter T-H Chen, Christopher PL-H Ramirez, Maria J Francis, Paul T |
Keywords: | Science & Technology Life Sciences & Biomedicine Neurosciences Neurosciences & Neurology Alzheimer's disease APOE choline acetyltransferase acetyl cholinesterase muscarinic receptors nicotinic receptors CEREBRAL AMYLOID ANGIOPATHY APOLIPOPROTEIN-E GENOTYPE M1 MUSCARINIC RECEPTORS NICOTINIC RECEPTOR SENILE DEMENTIA RAT-BRAIN ACETYLTRANSFERASE ACTIVITY TRANSGENIC MICE PROTEIN-KINASE E4 ALLELE |
Issue Date: | 1-Jun-2006 | Publisher: | ACADEMIC PRESS INC ELSEVIER SCIENCE | Citation: | Lai, Mitchell KP, Tsang, Shirley WY, Garcia-Alloza, Monica, Minger, Stephen L, Nicoll, James AR, Esiri, Margaret M, Wong, Peter T-H, Chen, Christopher PL-H, Ramirez, Maria J, Francis, Paul T (2006-06-01). Selective effects of the APOE epsilon 4 allele on presynaptic cholinergic markers in the neocortex of Alzheimer's disease. NEUROBIOLOGY OF DISEASE 22 (3) : 555-561. ScholarBank@NUS Repository. https://doi.org/10.1016/j.nbd.2005.12.016 | Abstract: | The effects of the APOE ε4 allele on a range of pre- and postsynaptic cholinergic markers were studied in a cohort of community-based Alzheimer's disease (AD) patients. Compared with age-matched controls, the postmortem AD neocortex showed decreased choline acetyltransferase (ChAT) and acetyl cholinesterase activities, lower muscarinic M2, and nicotinic α4β2 receptor densities, as well as reduced M1 receptor coupling to G-proteins. However, the ε4 allele was dose-dependently correlated only with higher losses of ChAT activities. AD patients with two ε4 alleles also had more β-amyloid containing senile plaques in the temporal cortex compared to patients with 0/1 ε4. This study suggests that APOE ε4 selectively affects presynaptic cholinergic function which may contribute to the clinical and neuropathological features of AD. © 2005 Elsevier Inc. All rights reserved. | Source Title: | NEUROBIOLOGY OF DISEASE | URI: | https://scholarbank.nus.edu.sg/handle/10635/188370 | ISSN: | 09699961 1095953X |
DOI: | 10.1016/j.nbd.2005.12.016 |
| Appears in Collections: | Staff Publications Elements |
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