Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.nbd.2005.12.016
Title: Selective effects of the APOE epsilon 4 allele on presynaptic cholinergic markers in the neocortex of Alzheimer's disease
Authors: Lai, Mitchell KP 
Tsang, Shirley WY 
Garcia-Alloza, Monica
Minger, Stephen L
Nicoll, James AR
Esiri, Margaret M
Wong, Peter T-H 
Chen, Christopher PL-H 
Ramirez, Maria J
Francis, Paul T
Keywords: Science & Technology
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
Alzheimer's disease
APOE
choline acetyltransferase
acetyl cholinesterase
muscarinic receptors
nicotinic receptors
CEREBRAL AMYLOID ANGIOPATHY
APOLIPOPROTEIN-E GENOTYPE
M1 MUSCARINIC RECEPTORS
NICOTINIC RECEPTOR
SENILE DEMENTIA
RAT-BRAIN
ACETYLTRANSFERASE ACTIVITY
TRANSGENIC MICE
PROTEIN-KINASE
E4 ALLELE
Issue Date: 1-Jun-2006
Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation: Lai, Mitchell KP, Tsang, Shirley WY, Garcia-Alloza, Monica, Minger, Stephen L, Nicoll, James AR, Esiri, Margaret M, Wong, Peter T-H, Chen, Christopher PL-H, Ramirez, Maria J, Francis, Paul T (2006-06-01). Selective effects of the APOE epsilon 4 allele on presynaptic cholinergic markers in the neocortex of Alzheimer's disease. NEUROBIOLOGY OF DISEASE 22 (3) : 555-561. ScholarBank@NUS Repository. https://doi.org/10.1016/j.nbd.2005.12.016
Abstract: The effects of the APOE ε4 allele on a range of pre- and postsynaptic cholinergic markers were studied in a cohort of community-based Alzheimer's disease (AD) patients. Compared with age-matched controls, the postmortem AD neocortex showed decreased choline acetyltransferase (ChAT) and acetyl cholinesterase activities, lower muscarinic M2, and nicotinic α4β2 receptor densities, as well as reduced M1 receptor coupling to G-proteins. However, the ε4 allele was dose-dependently correlated only with higher losses of ChAT activities. AD patients with two ε4 alleles also had more β-amyloid containing senile plaques in the temporal cortex compared to patients with 0/1 ε4. This study suggests that APOE ε4 selectively affects presynaptic cholinergic function which may contribute to the clinical and neuropathological features of AD. © 2005 Elsevier Inc. All rights reserved.
Source Title: NEUROBIOLOGY OF DISEASE
URI: https://scholarbank.nus.edu.sg/handle/10635/188370
ISSN: 09699961
1095953X
DOI: 10.1016/j.nbd.2005.12.016
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