Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.nbd.2005.12.016
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dc.titleSelective effects of the APOE epsilon 4 allele on presynaptic cholinergic markers in the neocortex of Alzheimer's disease
dc.contributor.authorLai, Mitchell KP
dc.contributor.authorTsang, Shirley WY
dc.contributor.authorGarcia-Alloza, Monica
dc.contributor.authorMinger, Stephen L
dc.contributor.authorNicoll, James AR
dc.contributor.authorEsiri, Margaret M
dc.contributor.authorWong, Peter T-H
dc.contributor.authorChen, Christopher PL-H
dc.contributor.authorRamirez, Maria J
dc.contributor.authorFrancis, Paul T
dc.date.accessioned2021-04-06T01:11:35Z
dc.date.available2021-04-06T01:11:35Z
dc.date.issued2006-06-01
dc.identifier.citationLai, Mitchell KP, Tsang, Shirley WY, Garcia-Alloza, Monica, Minger, Stephen L, Nicoll, James AR, Esiri, Margaret M, Wong, Peter T-H, Chen, Christopher PL-H, Ramirez, Maria J, Francis, Paul T (2006-06-01). Selective effects of the APOE epsilon 4 allele on presynaptic cholinergic markers in the neocortex of Alzheimer's disease. NEUROBIOLOGY OF DISEASE 22 (3) : 555-561. ScholarBank@NUS Repository. https://doi.org/10.1016/j.nbd.2005.12.016
dc.identifier.issn09699961
dc.identifier.issn1095953X
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/188370
dc.description.abstractThe effects of the APOE ε4 allele on a range of pre- and postsynaptic cholinergic markers were studied in a cohort of community-based Alzheimer's disease (AD) patients. Compared with age-matched controls, the postmortem AD neocortex showed decreased choline acetyltransferase (ChAT) and acetyl cholinesterase activities, lower muscarinic M2, and nicotinic α4β2 receptor densities, as well as reduced M1 receptor coupling to G-proteins. However, the ε4 allele was dose-dependently correlated only with higher losses of ChAT activities. AD patients with two ε4 alleles also had more β-amyloid containing senile plaques in the temporal cortex compared to patients with 0/1 ε4. This study suggests that APOE ε4 selectively affects presynaptic cholinergic function which may contribute to the clinical and neuropathological features of AD. © 2005 Elsevier Inc. All rights reserved.
dc.language.isoen
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectNeurosciences
dc.subjectNeurosciences & Neurology
dc.subjectAlzheimer's disease
dc.subjectAPOE
dc.subjectcholine acetyltransferase
dc.subjectacetyl cholinesterase
dc.subjectmuscarinic receptors
dc.subjectnicotinic receptors
dc.subjectCEREBRAL AMYLOID ANGIOPATHY
dc.subjectAPOLIPOPROTEIN-E GENOTYPE
dc.subjectM1 MUSCARINIC RECEPTORS
dc.subjectNICOTINIC RECEPTOR
dc.subjectSENILE DEMENTIA
dc.subjectRAT-BRAIN
dc.subjectACETYLTRANSFERASE ACTIVITY
dc.subjectTRANSGENIC MICE
dc.subjectPROTEIN-KINASE
dc.subjectE4 ALLELE
dc.typeArticle
dc.date.updated2021-04-03T05:10:04Z
dc.contributor.departmentDEPT OF PHARMACOLOGY
dc.description.doi10.1016/j.nbd.2005.12.016
dc.description.sourcetitleNEUROBIOLOGY OF DISEASE
dc.description.volume22
dc.description.issue3
dc.description.page555-561
dc.description.placeUNITED KINGDOM
dc.published.statePublished
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