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Title: Antenatal Mental Health and Retinal Vascular Caliber in Pregnant Women
Authors: Li LJ 
Ikram MK 
Broekman BF
Cheung CY 
Chen H
Gooley JJ 
Soh SE 
Gluckman P
Kwek K 
Chong YS 
Meaney M
Wong TY 
Saw SM. 
Keywords: antenatal mental health
retinal vascular caliber
antenatal depression
poor sleep quality
Issue Date: Feb-2013
Publisher: Association for Research in Vision and Ophthalmology
Citation: Li LJ, Ikram MK, Broekman BF, Cheung CY, Chen H, Gooley JJ, Soh SE, Gluckman P, Kwek K, Chong YS, Meaney M, Wong TY, Saw SM. (2013-02). Antenatal Mental Health and Retinal Vascular Caliber in Pregnant Women. Translational Vision Science and Technology 2 (2) : 1-10. ScholarBank@NUS Repository.
Abstract: Purpose: Depression, anxiety, and poor sleep are associated with increased risks of cardiovascular diseases. Previous studies have demonstrated the relationship between negative emotion and retinal microvascular changes among adults, yet no study has been done in pregnant women so far. This study aims to examine the association of antenatal mental health and retinal vascular caliber among Asian pregnant women. Methods: Nine hundred and fifty two Asian pregnant women aged 18 to 46 years were included in this study, who were recruited from two Singapore cohort studies, the Growing Up in Singapore Towards Healthy Outcomes (GUSTO) study and the In Vitro Fertilization (IVF) study conducted from 2009 onwards. A total of 835 Asian pregnant women underwent retinal photography at 26 weeks follow up, of whom 800 had gradable photographs. Symptoms of depression, anxiety, and sleep quality were assessed with self-administered questionnaires. Results: In multiple linear regression models adjusted for age, ethnicity, household income, pregnancy outcome history, means of conception, hypertension history, diabetes history, cigarette smoking history, mean arterial blood pressure, body mass index, and spherical equivalent, each standard deviation (SD) increase in the Edinburgh Postnatal Depression Scale (EPDS) (4.49 scores) and in the Pittsburgh Sleep Quality Index (PSQI) (2.90 scores) was associated with a 0.80 μm (P = 0.03) and a 1.22 μm (P = 0.01) widening in retinal arteriolar caliber, respectively. Conclusions: Our study demonstrates relationships of antenatal depressive symptoms and poor sleep quality with retinal arteriolar widening in pregnant women. Translational Relevance: We speculate that this might possibly indicate an effect of antenatal depression and poor sleep on the microcirculation during pregnancy.
Source Title: Translational Vision Science and Technology
ISSN: 21642591
DOI: 10.1167/tvst.2.2.2
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