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https://doi.org/10.1158/1078-0432.CCR-06-0774
Title: | Two distinct types of blood vessels in clear cell renal cell carcinoma have contrasting prognostic implications | Authors: | Yao, X Qian, C.-N Zhang, Z.-F Tan, M.-H Kort, E.J Yang, X.J Resau, J.H Teh, B.T |
Keywords: | CD31 antigen CD34 antigen adult article blood vessel cancer grading cancer survival controlled study female histopathology human human cell human tissue image analysis kidney carcinoma kidney parenchyma major clinical study male nephrectomy pericyte priority journal prognosis tissue microarray tumor vascularization Aged Antigens, CD31 Antigens, CD34 Blood Vessels Carcinoma, Renal Cell Disease-Free Survival Female Humans Immunohistochemistry Kidney Male Microcirculation Middle Aged Neovascularization, Pathologic Oligonucleotide Array Sequence Analysis Prognosis Treatment Outcome |
Issue Date: | 2007 | Citation: | Yao, X, Qian, C.-N, Zhang, Z.-F, Tan, M.-H, Kort, E.J, Yang, X.J, Resau, J.H, Teh, B.T (2007). Two distinct types of blood vessels in clear cell renal cell carcinoma have contrasting prognostic implications. Clinical Cancer Research 13 (1) : 161-169. ScholarBank@NUS Repository. https://doi.org/10.1158/1078-0432.CCR-06-0774 | Rights: | Attribution 4.0 International | Abstract: | Purpose: Intratumoral microvascular density (MVD) has been controversial as an indicator of prognosis in clear cell renal cell carcinoma (CCRCC). Classification of the intratumoral blood vessels based on differential expressions of blood vessel markers has not been correlated with patient prognosis in CCRCC. In this study, we aimed to evaluate the association of different categories of blood vessels with the patients' outcomes. Experimental Design: Seventy-eight CCRCC patients who underwent nephrectomy alone were enrolled. Paraffin-embedded CCRCC tissues, together with 16 nonmalignant kidney cortex tissues, were used in tissue microarray analyses and conventional section analyses. The characteristics of intratumoral blood vessels were identified by multiple blood vessel markers and pericyte markers. A computerized image analysis program was used to quantitatively calculate the vascular density. Results: Two distinct types of microvessels were identified in CCRCC: undifferentiated (CD31+/ CD34-) and differentiated (CD34+) vessels. A higher undifferentiated MVD significantly correlated with higher tumor grades and shorter patient survival. In contrast, a higher differentiated MVD significantly correlated with lower tumor grade and longer survival. Multivariate analyses showed that undifferentiated MVD was an independent prognostic factor for patient survival. An inverse correlation between undifferentiated MVD and differentiated MVD was also identified in CCRCC. Conclusions: This is the first report showing distinct types of vasculature in CCRCC correlated with contrasting prognoses. A refined classification of CCRCC based on vasculature is therefore important for evaluating prognosis, and it may also have therapeutic implications. © 2007 American Association for Cancer Research. | Source Title: | Clinical Cancer Research | URI: | https://scholarbank.nus.edu.sg/handle/10635/181048 | ISSN: | 1078-0432 | DOI: | 10.1158/1078-0432.CCR-06-0774 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
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