Please use this identifier to cite or link to this item: https://doi.org/10.1158/1078-0432.CCR-06-0774
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dc.titleTwo distinct types of blood vessels in clear cell renal cell carcinoma have contrasting prognostic implications
dc.contributor.authorYao, X
dc.contributor.authorQian, C.-N
dc.contributor.authorZhang, Z.-F
dc.contributor.authorTan, M.-H
dc.contributor.authorKort, E.J
dc.contributor.authorYang, X.J
dc.contributor.authorResau, J.H
dc.contributor.authorTeh, B.T
dc.date.accessioned2020-10-27T07:02:05Z
dc.date.available2020-10-27T07:02:05Z
dc.date.issued2007
dc.identifier.citationYao, X, Qian, C.-N, Zhang, Z.-F, Tan, M.-H, Kort, E.J, Yang, X.J, Resau, J.H, Teh, B.T (2007). Two distinct types of blood vessels in clear cell renal cell carcinoma have contrasting prognostic implications. Clinical Cancer Research 13 (1) : 161-169. ScholarBank@NUS Repository. https://doi.org/10.1158/1078-0432.CCR-06-0774
dc.identifier.issn1078-0432
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/181048
dc.description.abstractPurpose: Intratumoral microvascular density (MVD) has been controversial as an indicator of prognosis in clear cell renal cell carcinoma (CCRCC). Classification of the intratumoral blood vessels based on differential expressions of blood vessel markers has not been correlated with patient prognosis in CCRCC. In this study, we aimed to evaluate the association of different categories of blood vessels with the patients' outcomes. Experimental Design: Seventy-eight CCRCC patients who underwent nephrectomy alone were enrolled. Paraffin-embedded CCRCC tissues, together with 16 nonmalignant kidney cortex tissues, were used in tissue microarray analyses and conventional section analyses. The characteristics of intratumoral blood vessels were identified by multiple blood vessel markers and pericyte markers. A computerized image analysis program was used to quantitatively calculate the vascular density. Results: Two distinct types of microvessels were identified in CCRCC: undifferentiated (CD31+/ CD34-) and differentiated (CD34+) vessels. A higher undifferentiated MVD significantly correlated with higher tumor grades and shorter patient survival. In contrast, a higher differentiated MVD significantly correlated with lower tumor grade and longer survival. Multivariate analyses showed that undifferentiated MVD was an independent prognostic factor for patient survival. An inverse correlation between undifferentiated MVD and differentiated MVD was also identified in CCRCC. Conclusions: This is the first report showing distinct types of vasculature in CCRCC correlated with contrasting prognoses. A refined classification of CCRCC based on vasculature is therefore important for evaluating prognosis, and it may also have therapeutic implications. © 2007 American Association for Cancer Research.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectCD31 antigen
dc.subjectCD34 antigen
dc.subjectadult
dc.subjectarticle
dc.subjectblood vessel
dc.subjectcancer grading
dc.subjectcancer survival
dc.subjectcontrolled study
dc.subjectfemale
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman cell
dc.subjecthuman tissue
dc.subjectimage analysis
dc.subjectkidney carcinoma
dc.subjectkidney parenchyma
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectnephrectomy
dc.subjectpericyte
dc.subjectpriority journal
dc.subjectprognosis
dc.subjecttissue microarray
dc.subjecttumor vascularization
dc.subjectAged
dc.subjectAntigens, CD31
dc.subjectAntigens, CD34
dc.subjectBlood Vessels
dc.subjectCarcinoma, Renal Cell
dc.subjectDisease-Free Survival
dc.subjectFemale
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectKidney
dc.subjectMale
dc.subjectMicrocirculation
dc.subjectMiddle Aged
dc.subjectNeovascularization, Pathologic
dc.subjectOligonucleotide Array Sequence Analysis
dc.subjectPrognosis
dc.subjectTreatment Outcome
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1158/1078-0432.CCR-06-0774
dc.description.sourcetitleClinical Cancer Research
dc.description.volume13
dc.description.issue1
dc.description.page161-169
dc.published.statePublished
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