Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep46191
Title: Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity
Authors: Tang, T.H.-C
Alonso, S 
Ng, L.F.-P 
Thein, T.-L
Pang, V.J.-X 
Leo, Y.-S 
Lye, D.C.-B 
Yeo, T.-W
Keywords: autacoid
biological marker
cytokine
heparan sulfate
hyaluronic acid
acute disease
adult
blood
dengue
female
human
male
metabolism
middle aged
pathology
severity of illness index
Acute Disease
Adult
Biomarkers
Cytokines
Dengue
Female
Heparitin Sulfate
Humans
Hyaluronic Acid
Inflammation Mediators
Male
Middle Aged
Severity of Illness Index
Issue Date: 2017
Publisher: Nature Publishing Group
Citation: Tang, T.H.-C, Alonso, S, Ng, L.F.-P, Thein, T.-L, Pang, V.J.-X, Leo, Y.-S, Lye, D.C.-B, Yeo, T.-W (2017). Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity. Scientific Reports 7 : 46191. ScholarBank@NUS Repository. https://doi.org/10.1038/srep46191
Rights: Attribution 4.0 International
Abstract: Plasma leakage is a major pathogenic mechanism of severe dengue, but the etiology remains unclear. The association between endothelial glycocalyx integrity and vascular permeability in older adults with dengue has not been evaluated. A prospective cohort study of adults with undifferentiated fever screened for dengue by RT-PCR or NS1 antigen testing was performed. Patients were assessed daily while symptomatic and at convalescence. Serum hyaluronic acid (HA), heparan sulfate (HS) and selected cytokines (TNF-?, IL-6, IL-10) were measured on enrollment and convalescence. Patients were diagnosed as dengue fever (DF, n = 30), dengue hemorrhagic fever (DHF, n = 20) and non-dengue (ND) febrile illness (n = 11). Acute HA and HS levels were significantly higher in all dengue patients compared to ND (p = 0.0033 and p = 0.0441 respectively), but not different between DF and DHF (p = 0.3426 and p = 0.9180 respectively). Enrolment HA inversely correlated with serum albumin, protein and platelets in all dengue and DHF (p < 0.05). HA and HS in all dengue patients decreased significantly at convalescence. Serum IL-10 was significantly associated with HA in all dengue patients (p = 0.002). Serum HA and HS levels were increased in adult dengue and HA was associated with markers of disease severity. Endothelial glycocalyx damage may have a role in vascular leakage in dengue. © 2017 The Author(s).
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/179722
ISSN: 2045-2322
DOI: 10.1038/srep46191
Rights: Attribution 4.0 International
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