Please use this identifier to cite or link to this item: https://doi.org/10.1186/s12968-018-0496-1
Title: Validation of a rapid semi-automated method to assess left atrial longitudinal phasic strains on cine cardiovascular magnetic resonance imaging
Authors: Leng, S
Tan, R.-S 
Zhao, X
Allen, J.C 
Koh, A.S 
Zhong, L 
Keywords: adult
Article
cardiovascular magnetic resonance
cardiovascular parameters
cine magnetic resonance imaging
clinical effectiveness
clinical feature
controlled study
feasibility study
female
heart failure
heart failure mid range ejection fraction
heart failure with preserved ejection fraction
heart failure with reduced ejection fraction
human
hypertrophic cardiomyopathy
left atrial longitudinal phasic strain
major clinical study
male
middle aged
priority journal
reproducibility
validation study
aged
automation
case control study
cine magnetic resonance imaging
comparative study
computer assisted diagnosis
diagnostic imaging
heart atrium function
heart contraction
heart left ventricle function
pathophysiology
predictive value
procedures
Adult
Aged
Atrial Function, Left
Automation
Cardiomyopathy, Hypertrophic
Case-Control Studies
Female
Heart Failure
Humans
Image Interpretation, Computer-Assisted
Magnetic Resonance Imaging, Cine
Male
Middle Aged
Myocardial Contraction
Predictive Value of Tests
Reproducibility of Results
Ventricular Function, Left
Issue Date: 2018
Citation: Leng, S, Tan, R.-S, Zhao, X, Allen, J.C, Koh, A.S, Zhong, L (2018). Validation of a rapid semi-automated method to assess left atrial longitudinal phasic strains on cine cardiovascular magnetic resonance imaging. Journal of Cardiovascular Magnetic Resonance 20 (1) : 71. ScholarBank@NUS Repository. https://doi.org/10.1186/s12968-018-0496-1
Abstract: Background: Abnormal left atrial (LA) function is a marker of cardiac dysfunction and adverse cardiovascular outcome, but is difficult to assess, and hence not, routinely quantified. We aimed to determine the feasibility and effectiveness of a fast method to measure long-axis LA strain and strain rate (SR) with standard cardiovascular magnetic resonance (CMR) compared to conventional feature tracking (FT) derived longitudinal strain. Methods: We studied 50 normal controls, 30 patients with hypertrophic cardiomyopathy, and 100 heart failure (HF) patients, including 40 with reduced ejection fraction (HFrEF), 30 mid-range ejection fraction (HFmrEF) and 30 preserved ejection fraction (HFpEF). LA longitudinal strain and SR parameters were derived by tracking the distance between the left atrioventricular junction and a user-defined point at the mid posterior LA wall on standard cine CMR two- and four-chamber views. LA performance was analyzed at three distinct cardiac phases: reservoir function (reservoir strain ϵ s and strain rate SR s ), conduit function (conduit strain ϵ e and strain rate SR e ) and booster pump function (booster strain ϵ a and strain rate SR a ). Results: There was good agreement between LA longitudinal strain and SR assessed using the fast and conventional FT-CMR approaches (r = 0.89 to 0.99, p < 0.001). The fast strain and SRs showed a better intra- and inter-observer reproducibility and a 55% reduction in evaluation time (85 ± 10 vs. 190 ± 12 s, p < 0.001) compared to FT-CMR. Fast LA measurements in normal controls were 35.3 ± 5.2% for ϵ s , 18.1 ± 4.3% for ϵ e , 17.2 ± 3.5% for ϵ a , and 1.8 ± 0.4, - 2.0 ± 0.5, - 2.3 ± 0.6 s - 1 for the respective phasic SRs. Significantly reduced LA strains and SRs were observed in all patient groups compared to normal controls. Patients with HFpEF and HFmrEF had significantly smaller ϵ s , SR s , ϵ e and SR e than hypertrophic cardiomyopathy, and HFmrEF had significantly impaired LA reservoir and booster function compared to HFpEF. The fast LA strains and SRs were similar to FT-CMR for discriminating patients from controls (area under the curve (AUC) = 0.79 to 0.96 vs. 0.76 to 0.93, p = NS). Conclusions: Novel quantitative LA strain and SR derived from conventional cine CMR images are fast assessable parameters for LA phasic function analysis. © 2018 The Author(s).
Source Title: Journal of Cardiovascular Magnetic Resonance
URI: https://scholarbank.nus.edu.sg/handle/10635/176195
ISSN: 1097-6647
DOI: 10.1186/s12968-018-0496-1
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