Please use this identifier to cite or link to this item:
https://doi.org/10.1186/s12968-018-0496-1
DC Field | Value | |
---|---|---|
dc.title | Validation of a rapid semi-automated method to assess left atrial longitudinal phasic strains on cine cardiovascular magnetic resonance imaging | |
dc.contributor.author | Leng, S | |
dc.contributor.author | Tan, R.-S | |
dc.contributor.author | Zhao, X | |
dc.contributor.author | Allen, J.C | |
dc.contributor.author | Koh, A.S | |
dc.contributor.author | Zhong, L | |
dc.date.accessioned | 2020-09-14T08:27:04Z | |
dc.date.available | 2020-09-14T08:27:04Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Leng, S, Tan, R.-S, Zhao, X, Allen, J.C, Koh, A.S, Zhong, L (2018). Validation of a rapid semi-automated method to assess left atrial longitudinal phasic strains on cine cardiovascular magnetic resonance imaging. Journal of Cardiovascular Magnetic Resonance 20 (1) : 71. ScholarBank@NUS Repository. https://doi.org/10.1186/s12968-018-0496-1 | |
dc.identifier.issn | 1097-6647 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/176195 | |
dc.description.abstract | Background: Abnormal left atrial (LA) function is a marker of cardiac dysfunction and adverse cardiovascular outcome, but is difficult to assess, and hence not, routinely quantified. We aimed to determine the feasibility and effectiveness of a fast method to measure long-axis LA strain and strain rate (SR) with standard cardiovascular magnetic resonance (CMR) compared to conventional feature tracking (FT) derived longitudinal strain. Methods: We studied 50 normal controls, 30 patients with hypertrophic cardiomyopathy, and 100 heart failure (HF) patients, including 40 with reduced ejection fraction (HFrEF), 30 mid-range ejection fraction (HFmrEF) and 30 preserved ejection fraction (HFpEF). LA longitudinal strain and SR parameters were derived by tracking the distance between the left atrioventricular junction and a user-defined point at the mid posterior LA wall on standard cine CMR two- and four-chamber views. LA performance was analyzed at three distinct cardiac phases: reservoir function (reservoir strain ϵ s and strain rate SR s ), conduit function (conduit strain ϵ e and strain rate SR e ) and booster pump function (booster strain ϵ a and strain rate SR a ). Results: There was good agreement between LA longitudinal strain and SR assessed using the fast and conventional FT-CMR approaches (r = 0.89 to 0.99, p < 0.001). The fast strain and SRs showed a better intra- and inter-observer reproducibility and a 55% reduction in evaluation time (85 ± 10 vs. 190 ± 12 s, p < 0.001) compared to FT-CMR. Fast LA measurements in normal controls were 35.3 ± 5.2% for ϵ s , 18.1 ± 4.3% for ϵ e , 17.2 ± 3.5% for ϵ a , and 1.8 ± 0.4, - 2.0 ± 0.5, - 2.3 ± 0.6 s - 1 for the respective phasic SRs. Significantly reduced LA strains and SRs were observed in all patient groups compared to normal controls. Patients with HFpEF and HFmrEF had significantly smaller ϵ s , SR s , ϵ e and SR e than hypertrophic cardiomyopathy, and HFmrEF had significantly impaired LA reservoir and booster function compared to HFpEF. The fast LA strains and SRs were similar to FT-CMR for discriminating patients from controls (area under the curve (AUC) = 0.79 to 0.96 vs. 0.76 to 0.93, p = NS). Conclusions: Novel quantitative LA strain and SR derived from conventional cine CMR images are fast assessable parameters for LA phasic function analysis. © 2018 The Author(s). | |
dc.source | Unpaywall 20200831 | |
dc.subject | adult | |
dc.subject | Article | |
dc.subject | cardiovascular magnetic resonance | |
dc.subject | cardiovascular parameters | |
dc.subject | cine magnetic resonance imaging | |
dc.subject | clinical effectiveness | |
dc.subject | clinical feature | |
dc.subject | controlled study | |
dc.subject | feasibility study | |
dc.subject | female | |
dc.subject | heart failure | |
dc.subject | heart failure mid range ejection fraction | |
dc.subject | heart failure with preserved ejection fraction | |
dc.subject | heart failure with reduced ejection fraction | |
dc.subject | human | |
dc.subject | hypertrophic cardiomyopathy | |
dc.subject | left atrial longitudinal phasic strain | |
dc.subject | major clinical study | |
dc.subject | male | |
dc.subject | middle aged | |
dc.subject | priority journal | |
dc.subject | reproducibility | |
dc.subject | validation study | |
dc.subject | aged | |
dc.subject | automation | |
dc.subject | case control study | |
dc.subject | cine magnetic resonance imaging | |
dc.subject | comparative study | |
dc.subject | computer assisted diagnosis | |
dc.subject | diagnostic imaging | |
dc.subject | heart atrium function | |
dc.subject | heart contraction | |
dc.subject | heart left ventricle function | |
dc.subject | pathophysiology | |
dc.subject | predictive value | |
dc.subject | procedures | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Atrial Function, Left | |
dc.subject | Automation | |
dc.subject | Cardiomyopathy, Hypertrophic | |
dc.subject | Case-Control Studies | |
dc.subject | Female | |
dc.subject | Heart Failure | |
dc.subject | Humans | |
dc.subject | Image Interpretation, Computer-Assisted | |
dc.subject | Magnetic Resonance Imaging, Cine | |
dc.subject | Male | |
dc.subject | Middle Aged | |
dc.subject | Myocardial Contraction | |
dc.subject | Predictive Value of Tests | |
dc.subject | Reproducibility of Results | |
dc.subject | Ventricular Function, Left | |
dc.type | Article | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.description.doi | 10.1186/s12968-018-0496-1 | |
dc.description.sourcetitle | Journal of Cardiovascular Magnetic Resonance | |
dc.description.volume | 20 | |
dc.description.issue | 1 | |
dc.description.page | 71 | |
dc.published.state | Published | |
Appears in Collections: | Elements Staff Publications |
Show simple item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
10_1186_s12968-018-0496-1.pdf | 3.09 MB | Adobe PDF | OPEN | None | View/Download |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.