Please use this identifier to cite or link to this item:
|Title:||Value of a molecular screening program to support clinical trial enrollment in Asian cancer patients: The Integrated Molecular Analysis of Cancer (IMAC) Study||Authors:||Heong V.
Adam Isa Z.F.
Sy Lim J.
Lee S.-C., Goh B.-C.
|Keywords:||biomarker-driven clinical trials
|Issue Date:||2018||Publisher:||Wiley-Liss Inc.||Citation:||Heong V., Syn N.L., Lee X.W., Sapari N.S., Koh X.Q., Adam Isa Z.F., Sy Lim J., Lim D., Pang B., Thian Y.L., Ng L.K., Wong A.L., Soo R.A., Yong W.P., Chee C.E., Lee S.-C., Goh B.-C., Soong R., Tan D.S.P. (2018). Value of a molecular screening program to support clinical trial enrollment in Asian cancer patients: The Integrated Molecular Analysis of Cancer (IMAC) Study. International Journal of Cancer 142 (9) : 1890 - 1900. ScholarBank@NUS Repository. https://doi.org/10.1002/ijc.31091||Abstract:||The value of precision oncology initiatives in Asian contexts remains unresolved. Here, we review the institutional implementation of prospective molecular screening to facilitate accrual of patients into biomarker-driven clinical trials, and to explore the mutational landscape of advanced tumors occurring in a prospective cohort of Asian patients (n = 396) with diverse cancer types. Next-generation sequencing (NGS) and routine clinicopathological assays, such as immunohistochemistry, copy number analysis and in situ hybridization tests, were performed on tumor samples. Actionable biomarker results were used to identify eligibility for early-phase, biomarker-driven clinical trials. Overall, NGS was successful in 365 of 396 patients (92%), achieving a mean depth of 1,943× and coverage uniformity of 96%. The median turnaround time from sample receipt to return of genomic results was 26.0 days (IQR, 19.0–39.0 days). Reportable mutations were found in 300 of 365 patients (82%). Ninety-one percent of patients at study enrollment indicated consent to receive incidental findings and willingness to undergo genetic counseling if required. The most commonly mutated oncogenes included KRAS (19%), PIK3CA (16%), EGFR (5%), BRAF (3%) and KIT (3%); while the most frequently mutated tumor suppressor genes included TP53 (40%), SMARCB1 (12%), APC (8%), PTEN (6%) and SMAD4 (5%). Among 23 patients enrolled in genotype-matched trials, median progression-free survival was 2.9 months (IQR, 1.5–4.0 months). Nine of 20 evaluable patients (45%; 95% CI, 23.1–68.5%) derived clinical benefit, including 3 partial responses and 6 with stable disease lasting ≥ 8 weeks. © 2017 UICC||Source Title:||International Journal of Cancer||URI:||https://scholarbank.nus.edu.sg/handle/10635/175943||ISSN:||00207136||DOI:||10.1002/ijc.31091|
|Appears in Collections:||Elements|
Show full item record
Files in This Item:
|Value of a molecular screening program to support clinical trial enrollment in Asian cancer patients- The Integrated Molecular Analysis of Cancer (IMAC) Study.pdf||591.29 kB||Adobe PDF|
checked on Nov 25, 2020
checked on Nov 27, 2020
checked on Nov 27, 2020
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.