Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep17183
Title: A prospective case-control study to investigate retinal microvascular changes in acute dengue infection
Authors: Tan, P
Lye, D.C 
Yeo, T.K
Cheung, C.Y 
Thein, T.-L
Wong, J.G
Agrawal, R
Li, L.-J 
Wong, T.-Y 
Gan, V.C
Leo, Y.-S 
Teoh, S.C
Keywords: aspartate aminotransferase
creatinine
hemoglobin
acute disease
adult
blood
case control study
dengue
female
hematocrit
human
male
metabolism
microcirculation
microvasculature
pathophysiology
prospective study
retina
Acute Disease
Adult
Aspartate Aminotransferases
Case-Control Studies
Creatinine
Dengue
Female
Hematocrit
Hemoglobins
Humans
Male
Microcirculation
Microvessels
Prospective Studies
Retina
Issue Date: 2015
Publisher: Nature Publishing Group
Citation: Tan, P, Lye, D.C, Yeo, T.K, Cheung, C.Y, Thein, T.-L, Wong, J.G, Agrawal, R, Li, L.-J, Wong, T.-Y, Gan, V.C, Leo, Y.-S, Teoh, S.C (2015). A prospective case-control study to investigate retinal microvascular changes in acute dengue infection. Scientific Reports 5 : 17183. ScholarBank@NUS Repository. https://doi.org/10.1038/srep17183
Abstract: Dengue infection can affect the microcirculation by direct viral infection or activation of inflammation. We aimed to determine whether measured retinal vascular parameters were associated with acute dengue infection. Patients with acute dengue were recruited from Communicable Diseases Center, Singapore and age-gender-ethnicity matched healthy controls were selected from a population-based study. Retinal photographs were taken on recruitment and convalescence. A spectrum of quantitative retinal microvascular parameters (retinal vascular caliber, fractal dimension, tortuosity and branching angle) was measured using a semi-automated computer-based program. (Singapore I Vessel Assessment, version 3.0). We included 62 dengue patients and 127 controls. Dengue cases were more likely to have wider retinal arteriolar and venular calibers (158.3 ?m vs 144.3 ?m, p < 0.001; 227.7 ?m vs 212.8 ?m, p < 0.001; respectively), higher arteriolar and venular fractal dimensions (1.271 vs 1.249, p = 0.002; 1.268 vs. 1.230, p < 0.001, respectively), higher arteriolar and venular tortuosity (0.730 vs 0.546 [x104], p < 0.001; 0.849 vs 0.658 [x104], p < 0.001; respectively), compared to controls. Resolution of acute dengue coincided with decrease in retinal vascular calibers and venular fractal dimension. Dengue patients have altered microvascular network in the retina; these changes may reflect pathophysiological processes in the immune system.
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/175463
ISSN: 20452322
DOI: 10.1038/srep17183
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