Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-017-07574-1
Title: Endothelial dysfunction in systemic lupus erythematosus - A case-control study and an updated meta-analysis and meta-regression
Authors: Mak, A 
Kow, N.Y 
Schwarz, H 
Gong, L
Tay, S.H 
Ling, L.H 
Keywords: biological marker
adult
case control study
comorbidity
female
human
male
meta analysis
metabolism
middle aged
pathophysiology
regression analysis
systemic lupus erythematosus
vascular endothelium
vasodilatation
Adult
Biomarkers
Case-Control Studies
Comorbidity
Endothelium, Vascular
Female
Humans
Lupus Erythematosus, Systemic
Male
Middle Aged
Regression Analysis
Vasodilation
Issue Date: 2017
Citation: Mak, A, Kow, N.Y, Schwarz, H, Gong, L, Tay, S.H, Ling, L.H (2017). Endothelial dysfunction in systemic lupus erythematosus - A case-control study and an updated meta-analysis and meta-regression. Scientific Reports 7 (1) : 7320. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-017-07574-1
Abstract: Endothelium-dependent flow-mediated dilation (ED-FMD), a biophysical marker of endothelial dysfunction, is apparently impaired in patients with systemic lupus erythematosus (SLE) but such observation is inconsistent. Here, we assessed and compared the brachial artery ED-FMD (baED-FMD) using ultrasonography between SLE patients without cardiovascular disease and healthy controls (HC) matched for age, gender and body mass index. We then performed a comprehensive meta-analysis of case-control studies which compared baED-FMD between SLE patients and HC by determining the effect size of baED-FMD as standardized mean difference (SMD). Factors associated with the effect size were explored by mixed-model meta-regression. Seventy one SLE patients and 71 HC were studied. SLE patients had lower baED-FMD than HC (3.72 ± 2.8% vs 4.63 ± 3.1%, p = 0.032). Meta-analysis of 25 case-control studies involving 1,313 SLE patients and 1,012 HC with the random effects model revealed lower baED-FMD in SLE patients compared to HC (SMD -1.077, p < 0.001). The presence of diabetes mellitus (p = 0.04747), higher diastolic blood pressure (p = 0.044), renal involvement (p = 0.027) and aspirin use (p = 0.001) were associated with more discrepant baED-FMD between both groups. In conclusion, SLE patients naïve of cardiovascular disease have impaired endothelial function. Diabetes mellitus, renal disease and diastolic hypertension are major contributors of endothelial dysfunction in SLE patients. © 2017 The Author(s).
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/175180
ISSN: 20452322
DOI: 10.1038/s41598-017-07574-1
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