Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep29316
Title: Differential host susceptibility and bacterial virulence factors driving Klebsiella liver abscess in an ethnically diverse population
Authors: Lee, I.R 
Molton, J.S 
Wyres, K.L
Gorrie, C
Wong, J 
Hoh, C.H 
Teo, J
Kalimuddin, S 
Lye, D.C 
Archuleta, S 
Holt, K.E
Gan, Y.-H 
Keywords: aerobactin
antiinfective agent
bacterial protein
hydroxamic acid
phenol derivative
RmpA protein, Klebsiella pneumoniae
thiazole derivative
virulence factor
yersiniabactin
drug effect
ethnic group
female
genetics
genotype
human
Klebsiella infection
Klebsiella pneumoniae
liver
male
microbiology
pathogenicity
serotyping
Singapore
Anti-Bacterial Agents
Bacterial Proteins
Ethnic Groups
Female
Genotype
Humans
Hydroxamic Acids
Klebsiella Infections
Klebsiella pneumoniae
Liver
Male
Phenols
Serotyping
Singapore
Thiazoles
Virulence Factors
Issue Date: 2016
Publisher: Nature Publishing Group
Citation: Lee, I.R, Molton, J.S, Wyres, K.L, Gorrie, C, Wong, J, Hoh, C.H, Teo, J, Kalimuddin, S, Lye, D.C, Archuleta, S, Holt, K.E, Gan, Y.-H (2016). Differential host susceptibility and bacterial virulence factors driving Klebsiella liver abscess in an ethnically diverse population. Scientific Reports 6 : 29316. ScholarBank@NUS Repository. https://doi.org/10.1038/srep29316
Abstract: Hypervirulent Klebsiella pneumoniae is an emerging cause of community-acquired pyogenic liver abscess. First described in Asia, it is now increasingly recognized in Western countries, commonly afflicting those with Asian descent. This raises the question of genetic predisposition versus geospecific strain acquisition. We leveraged on the Antibiotics for Klebsiella Liver Abscess Syndrome Study (A-KLASS) clinical trial ongoing in ethnically diverse Singapore, to prospectively examine the profiles of 70 patients together with their isolates' genotypic and phenotypic characteristics. The majority of isolates belonged to capsule type K1, a genetically homogenous group corresponding to sequence-type 23. The remaining K2, K5, K16, K28, K57 and K63 isolates as well as two novel cps isolates were genetically heterogeneous. K1 isolates carried higher frequencies of virulence-associated genes including rmpA (regulator of mucoid phenotype A), kfu (Klebsiella ferric uptake transporter), iuc (aerobactin), iro (salmochelin) and irp (yersiniabactin) than non-K1 isolates. The Chinese in our patient cohort, mostly non-diabetic, had higher prevalence of K1 infection than the predominantly diabetic non-Chinese (Malays, Indian and Caucasian). This differential susceptibility to different capsule types among the various ethnic groups suggests patterns of transmission (e.g. environmental source, familial transmission) and/or genetic predisposition unique to each race despite being in the same geographical location.
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/174948
ISSN: 20452322
DOI: 10.1038/srep29316
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_1038_srep29316.pdf1.72 MBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

38
checked on Apr 7, 2021

Page view(s)

62
checked on Apr 9, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.