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Title: Cell type-specific regulation of immunological synapse dynamics by B7 ligand recognition
Authors: Brzostek, J 
Gascoigne, N.R.J 
Rybakin, V 
Keywords: B7 antigen
CD28 antigen
CD86 antigen
cytotoxic T lymphocyte antigen 4
interleukin 10
interleukin 2
interleukin 35
protein kinase C
transcription factor FOXP3
transforming growth factor beta
antigen expression
antigen presenting cell
cell motility
cell proliferation
down regulation
fluorescence resonance energy transfer
immune response
immunological synapse
ligand recognition
regulatory mechanism
regulatory T lymphocyte
Issue Date: 2016
Citation: Brzostek, J, Gascoigne, N.R.J, Rybakin, V (2016). Cell type-specific regulation of immunological synapse dynamics by B7 ligand recognition. Frontiers in Immunology 7 (FEB) : 24. ScholarBank@NUS Repository.
Abstract: B7 proteins CD80 (B7-1) and CD86 (B7-2) are expressed on most antigen-presenting cells and provide critical co-stimulatory or inhibitory input to T cells via their T-cell-expressed receptors: CD28 and CTLA-4. CD28 is expressed on effector T cells and regulatory T cells (Tregs), and CD28-dependent signals are required for optimum activation of effector T cell functions. CD28 ligation on effector T cells leads to formation of distinct molecular patterns and induction of cytoskeletal rearrangements at the immunological synapse (IS). CD28 plays a critical role in recruitment of protein kinase C (PKC)-? to the effector T cell IS. CTLA-4 is constitutively expressed on the surface of Tregs, but it is expressed on effector T cells only after activation. As CTLA-4 binds to B7 proteins with significantly higher affinity than CD28, B7 ligand recognition by cells expressing both receptors leads to displacement of CD28 and PKC-? from the IS. In Tregs, B7 ligand recognition leads to recruitment of CTLA-4 and PKC-? to the IS. CTLA-4 plays a role in regulation of T effector and Treg IS stability and cell motility. Due to their important rolesss in regulating T-cell-mediated responses, B7 receptors are emerging as important drug targets in oncology. In this review, we present an integrated summary of current knowledge about the role of B7 family receptor-ligand interactions in the regulation of spatial and temporal IS dynamics in effector and Tregs. © 2016 Brzostek, Gascoigne and Rybakin.
Source Title: Frontiers in Immunology
ISSN: 16643224
DOI: 10.3389/fimmu.2016.00024
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